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OpenTrials
Completed

NCT Number: NCT06502665

Second Ovulation Induction

Studies reported various risk factors for inadequate ovulation induction such as body mass index, low ovarian reserve, low baseline FSH and LH, and previous use of contraception or agonist.

The flexibility to use human chorionic gonadotropin (hCG) or gonadotropin-releasing hormone agonist (GnRHa) in ovulation induction for antagonist protocol or progestin primed ovarian stimulation (PPOS) is an advantage helping fertility doctors to decrease the risk of ovarian hyperstimulation syndrome. However, luteinizing hormone (LH) levels <15UI/L and progesterone ≤11.13nmol/L eight to twelve hours post GnRHa trigger were highly correlated to failed oocyte pickup (FOP).

Rescue hCG have been found to increase favorable outcomes in patients with FOP. The presence of false FOP could be due pharmaceutical reasons and human error. Genuine FOP could be due to intrinsic ovarian pathology.

The FOP is defined as the absence of oocytes after ovarian stimulation and follicular aspiration. It is an uncomfortable situation for the patient and medical team to deal with due to the apparent expectations of favorable results.

Ovulation induction could be via GnRHa, HCG, or both in antagonist protocol and PPOS protocol. Long or short agonist protocol could be triggered only via HCG.

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Key information

Conditions

IVF Genital Diseases Infertility Urogenital Diseases

Sex eligibility

Female

Study type

Observational

Primary location

Clinique Ovo

Montreal, Quebec, H4P 2S4, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Participants with no oocytes retrieved in the first ovum pick-up

Exclusion criteria

  • Error in trigger medication or timing by the patient/ medical team
  • Major absence of information (primary objective, trigger medication, time interval of trigger and ovum pick-up

Treatment and study plan

Women having had second ovulation induction after failed oocyte pick-up

Other

IVF success is defined by the number of retrieved oocytes. Identifying women at risk of failed oocyte pick-up at the first oocyte pick-up and optimizing their ovulation induction could enhance outcomes

Primary outcomes

  1. Oocyte pick-up at retrieval

    Time frame: 36 hours after ovulation triggering

    Number of retrieved oocytes after second ovulation induction in patients with FOP

Secondary outcomes

  1. Timing of ovulation triggering

    Time frame: 24 to 36 hours after ovulation triggering

    Time interval outcomes between trigger and ovum pickup

Sponsors and collaborators

Lead sponsor

Clinique Ovo

Industry

Registry information

Official study title

Outcomes From Secondary Ovulation Induction Following Failed Oocyte Pick-up IVF Cycles

Important dates

Study start
2024
Primary completion
2024
Study completion
2025
First posted
Jul 16, 2024
Registry last updated
Sep 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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