Seaweed-Derived Mineral-Rich Nutraceuticals in Cognition

Inclusion criteria

To be considered eligible for enrolment into the study, subjects must;

• Be able to give written informed consent.
• Be between 65 and 85 years of age (elderly cohort).
• If female, must be non-pregnant.
• Be in generally good health as determined by the investigator.

Exclusion criteria

Subjects will be excluded from the study if they meet any of the below criteria;

• Are less than 65 and greater than 85 years of age (elderly cohort).
• Are pregnant females.
• Are currently taking calcium/magnesium supplements, or have taken them in the past 14 days.
• Have a significant acute or chronic co-existing illness (cardiovascular, gastrointestinal, endocrinological, immunological, metabolic or any condition which contraindicates, in the investigators judgement, entry to the study).
• Have a score of <22 in the Montreal Cognitive Assessment (MoCA) (elderly cohort) and have no subjective memory impairment.
• Have a history of renal failure or renal disease, or eGFR creatinine levels below 30ml/min.
• Have diagnosis of significant low or high calcium or magnesium levels.
• Have a condition or are taking a medication that the investigator believes would interfere with the objectives of the study, pose a safety risk or confound the interpretation of the study results; to include misoprostrol, polystyrene sulfonate, Riociguat and vitamin/mineral supplements, probiotics or herbal remedies.
• Are individuals who, in the opinion of the investigator, are considered to be poor attendees or unlikely for any reason to be able to comply with the trial.
• Are receiving treatment involving experimental drugs.
• Have been in a recent experimental trial, these must have been completed not less than 30 days prior to this study.
• Have a malignant disease or any concomitant end-stage organ disease.
• Have a psychiatric illness which contraindicates entry to the study.