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OpenTrials
Completed

NCT Number: NCT05473975

Search for a Recanalization of the Sylvian Artery Electro-Physiological Biomarker

Early recanalization is a major prognostic factor in vascular accidents ischemic brain injury (AIC). The acute phase therapies of AIC aim to recanalization by intravenous thrombolysis and/or mechanical thrombectomy. Recanalization is identified immediately during thrombectomy by per-procedural arteriography. For the thrombolysis, only a performed MRI will validate the recanalization. This "proof of concept" study aims to identify an Electro-Encephalographic biomarker (EEG) of the recanalization in real time, the EEG being easy to set up. This biomarker will be sought during recanalization certified by thrombectomy in order to identify the window time for which the biomarker must be sought on the EEG. During this study, the identified EEG biomarker can be used to validate the recanalization during the intravenous thrombolysis in future studies

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Key information

Conditions

AIS

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Fondation Ophtalmologique A. de Rothschild

Paris, 75019, France

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient over 18 years old
  • Presenting a cerebral infarction with proximal occlusion of the sylvian artery requiring thrombectomy
  • No objection to participation in the study

Exclusion criteria

  • Pregnant or breastfeeding women
  • Patient benefiting from legal protection
  • Absence of affiliation to a social protection scheme
  • Recent cranial surgery not allowing the installation of a scalp EEG

Treatment and study plan

Placement of the EGG

Procedure

Placement of the EGG before the beginning of the thrombectomy

Primary outcomes

  1. IElectro-Encephalographic (EEG) marker of recanalization

    Time frame: inclusion visit

    dentification of an Electro-Encephalographic (EEG) marker of recanalization in patients with cerebral infarction with proximal occlusion of the sylvian artery and recanalized by mechanical thrombectomy

Sponsors and collaborators

Lead sponsor

Fondation Ophtalmologique Adolphe de Rothschild

Network

Registry information

Acronym: BEERS

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Jul 26, 2022
Registry last updated
Jun 25, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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