Skip to main content
OpenTrials
Active, Not Recruiting

NCT Number: NCT03274869

Scrub Typhus Infection Induced Cardiovascular Disease

Scrub typhus infection has been considered as seasonal and endemic infectious disorder with benign feature. However, the increasing mortality rate of scrub typhus has been recently reported in Southeast Asia and cause of death could be a fetal complicating cardiovascular disease. Therefore, the association and predictors for scrub typhus induced cardiovascular disease should be investigated to provide a timely and appropriate diagnosis and to reduce the mortality rate of complicated scrub typhus infection. Therefore, investigators prospectively investigate the association and predictors of cardiovascular disease in the participants with scrub typhus infection.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Scrub Typhus Bacterial Infections Bacterial Infections and Mycoses Cardiovascular Complication Gram-Negative Bacterial Infections Infections Rickettsiaceae Infections Vector Borne Diseases

Age range

19 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Chung-Buk University Hospital, Chungju, Chung Chung Do, South Korea

Loading trial locations.

About this study

Scrub typhus is a zoonotic disease caused by Orientia tsutsugamushi confined to East Asia including South Korea. It is characterized by fever, headache, rash, and eschar and the majority of patients without complications can recover with an early diagnosis and proper management with antibiotics. However, the increasing mortality rate of scrub typhus has been recently reported in Southeast Asia. Severe complications can be manifested by respiratory distress syndrome, renal failure, hepatic failure, and cardiovascular disease. Especially, cardiovascular complications can lead to cardiogenic shock and sudden cardiac arrest. Therefore, the association and predictors for scrub typhus induced cardiovascular disease should be investigated to provide a timely and appropriate diagnosis and to reduce the mortality rate of complicated scrub typhus infection. Therefore, investigators prospectively investigate the association and predictors of cardiovascular disease in the participants with scrub typhus infection admitted to 3rd referral centers in South Korea.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • any participants with scrub typhus infection

Exclusion criteria

  • patients under age of 18
  • pregnancy

Treatment and study plan

Primary outcomes

  1. Cardiovascular Mortality

    Time frame: one year

    Cardiovascular death including sudden cardiac death

Secondary outcomes

  1. Cardiovascular Complications

    Time frame: one year

    Atrial Fibrillation, Acute Heart Failure including acute myocarditis and Ischemic Heart Dease

Sponsors and collaborators

Lead sponsor

Eulji University Hospital

Other

Collaborators

  • Chung-Ang University Hospital
  • Chungbuk National University Hospital

Registry information

Official study title

Prediction and Early Diagnosis for Cardiovascular Disease Complicated by Scrub Typhus Infection

Important dates

Study start
2022
Primary completion
2026
Study completion
2027
First posted
Sep 7, 2017
Registry last updated
Mar 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.