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NCT Number: NCT04955535

Screening of Specific Genes for Pigmented Villous Nodular Synovitis

This study retrospectively analyzed the history of present illness of PVNS patients in our hospital. The enrolled patients were followed up by telephone to follow up their postoperative recovery and living conditions. Take the patient's pathological specimens for immunohistochemical testing, evaluate the relationship between the expression of different molecular targets, clinical manifestations and patient prognosis, and explore new molecular targets related to disease diagnosis and treatment.

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Key information

Conditions

Pigmented Villonodular Synovitis Giant Cell Tumor of Tendon Sheath Giant Cell Tumors Joint Diseases Muscular Diseases Musculoskeletal Diseases Neoplasms Neoplasms by Histologic Type Neoplasms, Connective Tissue Neoplasms, Connective and Soft Tissue Synovitis Synovitis, Pigmented Villonodular Tendinopathy

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Institute of Sports Medicine, Peking University Third Hospital, Beijing Key Laboratory of Sports Injuries， Beijing, China

Beijing, Beijing Municipality, 100191, China

About this study

This study retrospectively analyzed the symptoms, time of onset, injury history, laboratory examinations, imaging examinations, and intraoperative conditions of PVNS patients in our hospital. The enrolled patients were followed up by telephone to follow up their postoperative recovery and living conditions (VAS score, SF-36 score). Take the patient's pathological specimens for immunohistochemical testing, evaluate the relationship between the expression of different molecular targets, clinical manifestations and patient prognosis, and explore new molecular targets related to disease diagnosis and treatment.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinical diagnosis of pigmented villonodular synovitis.
  • Clinical diagnosis of giant cell tumor of tendon sheath

Exclusion criteria

  • No surgical treatment.
  • There were no pathological specimens during the operation.
  • The age of the patient is less than 18 years old or more than 60 years old.
  • The operation record shows nodular type.

Treatment and study plan

Arthroscopic synovectomy

Procedure

Arthroscopic synovectomy

Primary outcomes

  1. Difference of scale score between immunohistochemistry positive group and negative group

    Time frame: One week after surgery

    Difference of Visual Analog Score for pain between CSF-1 immunohistochemistry positive group and negative group

  2. Difference of Visual Analog Score for pain between TNF-α immunohistochemistry positive group and negative group

    Time frame: One week after surgery

    Difference of Visual Analog Score for pain between TNF-α immunohistochemistry positive group and negative group

  3. Difference of Visual Analog Score for pain between IL-1B immunohistochemistry positive group and negative group

    Time frame: One week after surgery

    Difference of Visual Analog Score for pain between IL-1B immunohistochemistry positive group and negative group

  4. Difference of SF-36 score between CSF-1 immunohistochemistry positive group and negative group

    Time frame: One week after surgery

    Difference of SF-36 score between CSF-1 immunohistochemistry positive group and negative group

  5. Difference of SF-36 score between TNF-α immunohistochemistry positive group and negative group

    Time frame: One week after surgery

    Difference of SF-36 score between TNF-α immunohistochemistry positive group and negative group

  6. Difference of SF-36 score between IL-1B immunohistochemistry positive group and negative group

    Time frame: One week after surgery

    Difference of SF-36 score between IL-1B immunohistochemistry positive group and negative group

Secondary outcomes

  1. Correlation between basic demographic characteristics and scale scores

    Time frame: One week after surgery

    Correlation between age, gender and scale score

Sponsors and collaborators

Lead sponsor

Peking University Third Hospital

Other

Registry information

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Jul 8, 2021
Registry last updated
Jul 8, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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