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NCT Number: NCT05762731

Screening for Lung Cancer in Subjects With Family History of Lung Cancer

Lung cancer can be detected via screening of high-risk individuals, i.e current or ex-heavy smokers, with low-dose computer tomography (LDCT) of thorax. The National Lung Screening Trial in US and the NELSON trial in Europe demonstrated reduction in lung cancer mortality with LDCT screening for lung cancer. In Hong Kong, however, there is a prominence of female never-smokers with lung cancer. There is no identifiable risk factors for non-smokers with lung cancer except family history of lung cancer. The hypothesis is that lung cancer screening for subjects with family history of lung cancer, can detect early lung cancer.

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Key information

Conditions

Lung Cancer Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

50 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Hong Kong

Hong Kong

Location status: Recruiting

Location contact

David CL Lam, MBBS, FRCP(Edin), FCCP, FACP

CONTACT

[email protected]

+852 2255 5814

About this study

The primary aim of this prospective study is to find out the rate of lung cancer detection in subjects who are first degree relatives of lung cancer patients. Secondary aims include studying the characteristics of screen-detected lung cancer. This is a multi-centered prospective cohort study. 1,520 subjects who are first degree relatives of lung cancer patients at four public hospitals in Hong Kong will be screened. Intervention Detailed questionnaires and LDCT Thorax will be performed. The primary outcome measure is the number of lung cancers detected by this study. The screening-detection rate of lung cancer in first-degree relatives of lung cancer patients will be estimated.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 50-75, men or women, smokers or non-smokers
  • Being first degree relatives (Siblings, children, and parents) of lung cancer subjects
  • Having no known lung cancer before

Exclusion criteria

  • Non-Chinese
  • Mentally incompetent to give informed consent

Treatment and study plan

Low dose CT thorax

Diagnostic Test

A multi-detector row CT scanner with minimum section collimation of ≤1 mm and minimum number of data acquisition channels ≥ 16will be employed.

Primary outcomes

  1. The rate of lung cancer detection in subjects with family history of lung cancer

    Time frame: An average of 2.5 years

    The number of screening-detected lung cancer among first degree relatives of lung cancer patients.

Secondary outcomes

  1. The characteristics of screening detected lung cancer

    Time frame: An average of 2.5 years

    Stage distribution of lung cancer detected.

Sponsors and collaborators

Lead sponsor

The University of Hong Kong

Other

Collaborators

  • Hong Kong Sanatorium & Hospital
  • Kwong Wah Hospital
  • The Queen Elizabeth Hospital

Registry information

Important dates

Study start
2023
Primary completion
2028
Study completion
2028
First posted
Mar 10, 2023
Registry last updated
Jun 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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