Screening Elderly Patients for Weaning

In the context of a multicentre, pilot trial in 100 elderly (>/= 65 years) critically ill adults comparing two strategies to identify weaning candidates ('once daily' vs. 'at least twice daily' screening) in 8 ICUs across Canada, we propose to assess feasibility metrics that reflect our ability to consent, enroll and recruit elderly and very elderly invasively ventilated patients and evaluate adherence to the study protocols in preparation for launching a large scale screening RCT.

• Primary Research Question (i) Can we recruit invasively ventilated elderly (age >/= 65 years) critically ill adults into a weaning trial comparing alternative screening strategies?
• Secondary Research Questions (ii) Can clinicians adhere to the assigned screening protocols in both study arms?
• Tertiary Research Questions

(ii) What are the proportions of enrolled elderly and very elderly trial participants? (iii) Are the proportions of consents obtained and declined for trial participation similar between eligible elderly and very elderly trial participants? (iv) What are the rates and reasons for trial exclusion based between eligible elderly and very elderly patients? (v) What effect, in preliminary estimates, do the alternative screening strategies have on clinically important outcomes[e.g., time to first Spontaneous Breathing Trial (SBT) and first successful SBT, time to first extubation and successful extubation, total duration of mechanical ventilation, intensive care unit (ICU) and hospital length of stay, ICU and hospital mortality, use of noninvasive ventilation (NIV) following extubation, complications (self-extubation, tracheostomy, reintubation, proportion requiring prolonged mechanical ventilation) and adverse events] between elderly and very elderly trial participants.

• Quaternary Research Questions

(i) Can we assess and quantify current practices related to sedation, analgesia an delirium management and mobilization before conducting 'once daily' or 'at least twice daily screening' assessments of weaning readiness with the goal of quantifying factors that may lead to performance bias in the future, planned, large scale weaning trial.

(ii) Can we identify barriers (clinician and institutional) to recruitment into this study? (iii) Can we classify trial participants as requiring (i) simple, (ii) difficult or (iii) prolonged weaning using the 'Task Force on Weaning' definitions.

Hypotheses

We hypothesize that we will achieve our feasibility metrics, specifically, that:

• We will recruit at least 2 elderly critically ill patients, on average, per month per ICU.
• Compliance rates will be at least 80% in both study arms and contamination in the once daily screening arm will be < 10%.
• We expect that we will enroll similar proportions of elderly than very elderly trial participants.
• We anticipate that the proportion of consents obtained will be similar between eligible elderly and very elderly participants, the rate of declined consents will be higher in very elderly trial participants.
• We anticipate that rates of exclusion will be greater for very elderly trial participants due to increased prevalence of comorbid illnesses and treatment limitations.
• We expect that preliminary estimates of the impact of the alternative screening strategies on clinically important outcomes will be similar between elderly and very elderly trial participants.
• Practices in sedation, analgesia, delirium and mobilization will be recorded at least 80% of the time.
• We will identify potentially modifiable clinician and institutional barriers to recruitment.
• Proportions of critically ill adults requiring simple, difficult or prolonged weaning in Canadian ICUs will be similar to those reported in the world literature.

Inclusion criteria

The investigators will include:

• elderly (age >/= 65 years) critically ill adults
• receiving invasive mechanical ventilation for at least 24 hours who can breathe spontaneously on Pressure Support (PS) or trigger breaths on volume or pressure Assist Control (AC), volume or pressure Synchronized Intermittent Mandatory Ventilation (SIMV) ± PS, Pressure Regulated Volume Control (PRVC) or Airway Pressure Release Ventilation (APRV).
• patients must be receiving </= 70% inspired oxygen
• and a positive end-expiratory pressure of </= 12 cm H2O (Table 2). .

Exclusion criteria

The investigators will exclude patients who have already undergone extubation or an SBT, are unlikely to benefit (e.g. moribund, expected brain death), on automated weaning modes, participating in studies with a weaning protocol, and those who can not be optimized with regard to sedation and mobilization.

Specifically, we will exclude patients:

• admitted after cardiopulmonary arrest or with brain death or expected brain death,
• who have evidence of myocardial ischemia in the 24 hour period before enrollment,
• who have received continuous invasive mechanical ventilation for >/= 2 weeks,
• who have a tracheostomy in situ at the time of screening,
• who are receiving sedative infusions for seizures or alcohol withdrawal,
• who require escalating doses of sedative agents,
• who are receiving neuromuscular blockers or who have known quadriplegia, paraplegia or 4 limb weakness or paralysis preventing active mobilization (e.g., active range of motion, exercises in bed, sitting at edge of bed, transferring from bed to chair, standing, marching in place, ambulating),
• who are moribund (e.g., at imminent risk for death) or who have limitations of treatment (e.g., withdrawal of support, do not reintubate order, however, do not resuscitate orders will be permitted),
• who have profound neurologic deficits (e.g. large intracranial stroke or bleed) or Glasgow Coma Scale (GCS) </= 6,
• who are using modes that automate SBT conduct,
• who are current enrolled in a confounding study that includes a weaning protocol,
• who were previously enrolled in this trial,
• patients who have already undergone an SBT or
• patients who have already undergone extubation [planned, unplanned (e.g. self, accidental)] during the same ICU admission.