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Completed

NCT Number: NCT01333826

Schooling, Income, and HIV Risk in Malawi

This study is designed to evaluate a two-year randomized intervention in Malawi that provides cash transfers to current schoolgirls (and young women who have recently dropped out of school) to stay in (and return to) school in order to understand the possible effects of such programs on the sexual behavior of the beneficiaries and their subsequent HIV risk.

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Key information

Age range

13 year–22 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Zomba District, Malawi

Zomba, Malawi

About this study

Motivation:

Education has been suggested as a "social vaccine" to prevent the spread of HIV (Jukes, Simmons, and Bundy, 2008), but almost all of the evidence we have on the link between school attendance (or attainment) and the risk of HIV infection comes from cross-sectional studies. Furthermore, the role of income (especially that of women's poverty) has been hypothesized as a significant factor in the spread of HIV in SSA, but again there is no credible evidence showing a causal link between income and HIV risk. A randomized intervention, such as the one proposed here, that provides randomly varied amounts of cash transfers to young individuals and their guardians is the perfect setting to examine the possible existence of such causal relationships.

Objectives:

The objective of the proposed study here is to provide credible evidence on issues about which we still know very little. Specifically, the main questions the study will try to answer are the following:

  • Are the observed effects of a CCT associated with the transfer or the conditionality imposed on the recipient?
  • Do the outcomes of interest improve with increased benefit levels set by the program?
  • Do CCT programs for schooling have any positive health impacts, including prevention of STIs such as HIV/AIDS among young people?

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • female
  • 13-22 years old
  • never married

Treatment and study plan

Zomba Cash Transfer Program

Behavioral

Cash transfers were provided monthly to a randomly selected sample of school aged girls. Amounts were also varied in both treatment arms.

Primary outcomes

  1. Sexually Transmitted Infections

    Time frame: 18 months

    HIV prevalence HSV-2 prevalence

  2. Schooling

    Time frame: 12 months/24 months

    school enrollment

Secondary outcomes

  1. Sexually Transmitted Infections

    Time frame: 18 months

    syphilis

  2. Marriage and fertility

    Time frame: 12 months/24 months

    ever married currently pregnant

  3. sexual behavior

    Time frame: 12 months/ 24 months

    new sexual debut unprotected sexual intercourse weekly sexual intercourse had a sexual partner 25 or older

  4. HIV Awareness

    Time frame: 12 months/24 months

    ever tested for HIV received health training on HIV HIV knowledge

Sponsors and collaborators

Lead sponsor

George Washington University

Other

Collaborators

  • University of California, San Diego
  • University of Malawi
  • World Bank

Registry information

Official study title

Does Schooling Protect Young Women From HIV?

Acronym: SIHR

Important dates

Study start
2007
Primary completion
2012
Study completion
2025
First posted
Apr 12, 2011
Registry last updated
Aug 20, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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