School Inner City Air Study

Classrooms from participating schools will be randomized to active vs. sham HEPA cleaners. From enrolled classrooms, we will enroll students, teachers, and members of the household. We will collect the following:

• longitudinal classroom air samples
• longitudinal upper respiratory samples
• longitudinal symptom surveys using the Wisconsin Upper Respiratory Symptom Survey (WURSS) Viral testing on collected air and respiratory samples will be performed using digital polymerase chain reaction (dPCR).

Inclusion criteria

Children

• Grades K-5 (age 6-12 years)
• Attend one of the schools that the study team has permission to obtain classroom/school environmental samples
• Have no plans to move schools within the upcoming 12 months
• Subject and/or parent guardian must be able to understand and provide informed consent and also willing to participate in the study

Adults

• Adult (age 21 or older) parent, caretaker, or household member of child participating in this study, or teacher in classroom participating in study
• Able to understand and provide informed consent

Exclusion criteria

Children

• Contraindication to or inability to participate in home self-collection of nasal swab samples
• Severe chronic diseases (e.g. cancer, genetic or congenital disorders interfering with mobility)
• Severe neurobehavioral, neurodevelopmental or psychiatric disorders requiring special assistance
• Families who do not speak English or Spanish well enough to complete the survey questions, as validated versions in other languages are not available for all of the measures

Adults

• Contraindication to or inability to participate in home self-collection of nasal swab samples
• Severe chronic diseases (e.g. cancer, genetic or congenital disorders interfering with mobility)
• Severe neurobehavioral, neurodevelopmental or psychiatric disorders requiring special assistance
• Families who do not speak English or Spanish well enough to complete the survey questions, as validated versions in other languages are not available for all of the measures