Schistosomiasis Effect on Response to Vaccines, Anaemia and Nutritional Status of Children of Northern Senegal

SchistoVAN aims to study the role of schistosomiasis infection in the modulation of the immune response of children to childhood vaccine antigens, as well as the impact of this infection on their nutritional status and their haemoglobinaemia.

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Key information

Conditions

Schistosomiasis Anemia Body Weight Digestive System Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Gastrointestinal Diseases Growth Disorders Helminthiasis Hematologic Diseases Hemic and Lymphatic Diseases Infections Intestinal Diseases Intestinal Diseases, Parasitic Intestinal Parasites Male Urogenital Diseases Parasitic Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Schistosomiasis haematobia Signs and Symptoms Stunting Thinness Trematode Infections Underweight Urinary Tract Infections Urogenital Diseases Urologic Diseases Vector Borne Diseases

Age range

6 year–10 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Biomedical Research Center EPLS

Saint-Louis, SL, Senegal

About this study

SchistoVAN aims to study the interactions between chronic parasite infections such as schistosomiasis and the immunological and nutritional status of children. In this scope, the investigators conducted a case-control study where one group of children is infected with schistosoma haematobium and the other is not infected with this parasite.

The investigators then stimulated whole blood of these children with various vaccine antigens to address their immune function and study the influence of schistosomiasis infectious state on their overall immune condition.

Aims of the study:

To evaluate the interaction between schistosomiasis and the nutritional status of children and their haemoglobinemia.

To evaluate the influence of schistosomiasis on children's specific immune response towards EPI vaccine antigens, the inflammatory status of children and nutritional serologic markers.

To compare schistosomiasis diagnostic tools (evaluation of circulating cathodic antigen (CCA) strip for diagnosis of urinary schistosomiasis in comparison with microscopy and urinary dipsticks)

To study prevalence of intestinal parasites such as Blastocystis hominis

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Members of AnoPalAnoVac cohort
Age: between 6 and 10 years

Exclusion criteria

body temperature > 38.5 ºC
malaria episode

Sponsors and collaborators

Lead sponsor

Biomedical Research Center EPLS

Other

Collaborators

Centre National de la Recherche Scientifique, France
Centre d'Infection et d'Immunité de Lille
Institut National de la Santé Et de la Recherche Médicale, France
Institut Pasteur de Lille
Région Nord-Pas de Calais, France
University of Lille Nord de France

Registry information

Official study title

Comparison of Schistosomiasis Diagnostic Techniques and Study of Schistosoma Infection on Children's Immune Response to Childhood Vaccines, on Anaemia and on Nutritional Status

Acronym: SchistoVAN

Important dates

Study start: 2011
Primary completion: 2011
Study completion: 2011
First posted: Mar 14, 2012
Registry last updated: Mar 14, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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