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OpenTrials
Completed

NCT Number: NCT04365595

SARS-CoV-2 Associated Respiratory Failure Recovery (COVID-19 CAir)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the current pandemic of coronavirus disease (COVID-19) that can lead to respiratory failure requiring oxygen therapy. Some patients develop acute respiratory distress syndrome (ARDS) and may die despite intensive care therapy. Currently it is unknown a) how fast patients recover after being discharged from hospital and b) what underlying predictors may influence recovery.

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Key information

Conditions

SARS-CoV 2 COVID

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospital Zurich

Zurich, 8091, Switzerland

About this study

Study aims:

  • To evaluate subjective and objective recovery after discharge from hospital in patients with respiratory failure due to COVID-19.
  • To identify risk factors for COVID-19 associated respiratory failure and prolonged recovery

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • hospitalization at University Hospital Zurich due to COVID-19 infection
  • hospital discharge max. 4 weeks ago
  • requiring supplemental oxygen

Exclusion criteria

  • <18 years
  • non-German speaking
  • no smartphone access

Treatment and study plan

Questionnaires, spirometry

Other

Questionnaires targeting health-related quality-of-life, symptoms, anxiety and depression

Primary outcomes

  1. Health-related quality-of-life

    Time frame: 3 months

    European Quality of Life - 5 Dimensions - 5 Levels Instrument (EQ-5D-5L). Scoring: Index ranges from 1 to <0, with lower scores indicating more limitations.

Secondary outcomes

  1. Anxiety and depression

    Time frame: 3 months

    Hospital Axiety and Depression Score (HADS). Scoring: Scores range from 0 to 42, with higher scores indicating more anxiety or depression symptoms.

  2. Symptom burden

    Time frame: 3 months

    COPD Assessment Test (CAT). Scoring: Scores range from 0-40, with higher scores indicating more symptoms due to respiratory limitations.

  3. Spirometry

    Time frame: 1 month

    Forced expiratory volume in one second (FEV1) in liters and percent predicted.

  4. Spirometry

    Time frame: 1 month

    Forced vital capacity (FVC) in liters and percent predicted.

Sponsors and collaborators

Lead sponsor

University of Zurich

Other

Registry information

Official study title

Recovery in Patients With SARS-CoV-2 Associated Respiratory Failure

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
Apr 28, 2020
Registry last updated
Feb 23, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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