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Completed

NCT Number: NCT05113758

Sarcopenia Measured by Ultrasound in Hospitalized Older Adults

Observational prospective study in older adults admitted to an Acute Geriatric Unit, in which sarcopenia will be evaluated by ultrasound in the anterior rectus femoris muscle.

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Key information

Conditions

Sarcopenia Atrophy Muscular Atrophy Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

69 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Complejo Hospitalario Universitario de Albacete

Albacete, 02006, Spain

About this study

The main objective of the study is to estimate, by means of portable ultrasound, parameters of muscle quantity and quality (anterior rectus femoris muscle area, width and echostructure ) in older adults hospitalized in Acute Geriatric Units for medical reasons.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients over 69 years of age.
  • Hospitalization for a medical cause in Acute Geriatric Units.
  • Holden's Functional Ambulation Classification Scale at level 1 or higher.
  • Informed consent signed by the patient or legal representative.

Exclusion criteria

  • Terminal condition or life expectancy of less than 6 months.
  • Impossibility or refusal to undergo muscle ultrasound.
  • Refusal for follow-up
  • Severe dementia stage Global Deteriorating Scale: 7
  • Impossibility in the opinion of the investigators to complete the necessary data for the study.

Treatment and study plan

Muscle Ultrasound

Diagnostic Test

All participants will undergo a muscle ultrasound on admission and at discharge

Primary outcomes

  1. Prevalence of sarcopenia on admission

    Time frame: 72 hours

    Prevalence of sarcopenia on admission. A prevalent case of sarcopenia will be considered if a patient fulfills the EWGSOP2 at admission

  2. Incidence of sarcopenia between admission and discharge

    Time frame: 15 days

    An incident case of sarcopenia will be considered if a patient not fulfilling EWGSOP2 diagnostic criteria on admission, will meet diagnostic criteria at discharge of sarcopenia at discharge (diagnosis will be considered as a dichotomous variable -yes/no-).

  3. Muscle mass (the anterior rectus femoris muscle)

    Time frame: 15 days

    The evolution of muscle mass between admission and discharge will be assessed by ultrasound

Secondary outcomes

  1. Minimal nutritional assessment (MNA-SF) score

    Time frame: 72 hours

    The mini-nutritional assessment - short form is a simple, non - invasive and validated scale for the detection of malnutrition in older adults. It takes into account the patient's loss of appetite, weight loss, motor skills, recent health status, neuropsychological disorders. The maximum score of the MNA-SF is 14:

    Greater than or equal to 11: normal nutritional status. Between 8 and 11: risk of malnutrition. Less than 8: malnutrition.

  2. Hand grip strength

    Time frame: 15 days

    Using a hand-held dynamometer

  3. 4-meter walking speed test

    Time frame: 15 days

    The evolution of the value of the 4-meter walking speed test between admission and discharge will be assessed.

  4. ADL (Activities of Daily Living) questionnaire

    Time frame: 3 months

    the ADL questionnaire will also be performed on admission, at discharge, and at 3 months.

  5. SPPB score (SHORT PHYSICAL PERFORMANCE BATTERY score)

    Time frame: 15 days

    Short Physical Performance Battery (SPPB): score range 0-12, higher score means a better outcome

  6. Mortality

    Time frame: 3 months

    Mortality will be measured with vital status at 3 months.

  7. Length of stay, days

    Time frame: 15 days

    Day of admission to day of discharge

  8. Readmission(s) after index hospitalization

    Time frame: 3 months

    Readmission(s) after index hospitalization, Dichotomous outcome (yes/no)

  9. Emergency department (ED) visit(s)

    Time frame: 3 months

    ED visit(s) after index hospitalization, Dichotomous outcome (yes/no)

Sponsors and collaborators

Lead sponsor

Pedro Abizanda

Other

Collaborators

  • Hospital Infanta Sofia
  • Hospital Universitario Getafe
  • Hospital Universitario Infanta Leonor
  • Hospital Universitario La Paz
  • Hospital Virgen del Valle de Toledo
  • Puerta de Hierro University Hospital

Registry information

Official study title

"SARCOPENIA MEASURED BY ULTRASOUND IN HOSPITALIZED OLDER ADULTS" (ECOSARC Study).

Acronym: ECOSARC

Important dates

Study start
2019
Primary completion
2022
Study completion
2022
First posted
Nov 9, 2021
Registry last updated
Aug 30, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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