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Completed

NCT Number: NCT07037979

Sarcopenia and Peripheral Artery Disease With Chronic Limb Threatening Ischemia

To evaluate the correlation of Sarcopenia Parameters and Peripheral Artery Disease with chronic limb threatening ischaemia.

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Key information

Conditions

Sarcopenia Arterial Occlusive Diseases Arteriosclerosis Atherosclerosis Atrophy Cardiovascular Diseases Chronic Disease Chronic Limb Threatening Ischemia Chronic Limb-Threatening Ischemia Disease Attributes Ischemia Muscular Atrophy Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pathologic Processes Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Peripheral Arterial Disease Peripheral Vascular Diseases Signs and Symptoms Vascular Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Huadong Hospital, Fudan University

Shanghai, 200040, China

About this study

Prior researches indicated a relatively high prevalence of sarcopenia among patients of Peripheral Artery Disease. However, the relationship between sarcopenia and progression of Peripheral Artery Disease with chronic limb threatening ischaemia remained poorly understood. Thus, this cohort study aimed to evaluate the correlation of Sarcopenia Parameters, such as psoas muscle area (PMA) and total abdominal muscle area (TAMA) at the L3 vertebral level, measured by computed tomography (CT), and progression of Peripheral Artery Disease with chronic limb threatening ischaemia.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients of Peripheral Artery Disease, including intermittent claudication and Chronic Limb Threatening Ischemia;
  • Patients with Rutherford grade 2-6 between Jan.1 2023 and Dec.31 2024;
  • Patients at age 18-80;
  • Patients underwent an in-hospital routine enhanced whole abdomen to lower extremities CT scan;
  • Patients able to complete the clinical follow-up for 3 months.

Exclusion criteria

  • Poor CT quality or incomplete images;
  • Incomplete clinical data;
  • In-hospital mortality during Jan.1 2023 and Dec.31 2024.

Treatment and study plan

Not applicable- observational study

Other

non-applicable

Primary outcomes

  1. psoas muscle area (PMA) [measured by computed tomography (CT)]

    Time frame: 2023.1.1～2024.12.31

    psoas muscle area (PMA) (square centimeters) was regarded as a kind of typical sarcopenia parameters, measured by computed tomography (CT) at the L3 vertebral level

  2. total abdominal muscle area (TAMA) measured by computed tomography (CT)

    Time frame: 2023.1.1～2024.12.31

    total abdominal muscle area (TAMA) (square centimeters) was regarded as a kind of typical sarcopenia parameters, measured by computed tomography (CT) at the L3 vertebral level

Sponsors and collaborators

Lead sponsor

Fudan University

Other

Registry information

Official study title

Correlation of Sarcopenia and Peripheral Artery Disease With Chronic Limb Threatening Ischemia

Acronym: SAC

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Jun 26, 2025
Registry last updated
Jun 26, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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