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NCT Number: NCT07013604

Sarcopenia and Intervention Physical Therapy

To evaluate and compare the effectiveness of neuromuscular electrical stimulation (NMES) and low-load resistance training with blood flow restriction (BFR) in improving muscle mass, strength, functional performance, and quality of life in elderly individuals diagnosed with sarcopenia

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Key information

Conditions

Sarcopenia Atrophy Muscular Atrophy Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

60 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Sarcopenia, the age-related decline in muscle mass, strength, and function, significantly affects the health and independence of elderly individuals. It increases the risk of frailty, falls, and disability. Neuromuscular electrical stimulation (NMES) and low-load resistance training with blood flow restriction (BFR) are promising rehabilitation strategies for older adults with limited physical capacity. This study aims to compare the effectiveness of NMES and BFR in managing sarcopenia and improving physical and functional outcomes in the elderly

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Older age (≥ 60-75 years)

Low muscle strength (e.g., low handgrip strength)

Low muscle mass (e.g., ASM/height² below cutoff)

Exclusion criteria

  • heart disese
  • kidny disese
  • autoimune disese
  • cognetive disorder
  • sever form of sarcopenia

Treatment and study plan

Neuromuscular Electrical Stimulation (NMES) Group,Resistance + BFR Group

Device

NMES Group: Receives neuromuscular electrical stimulation to the thigh muscles for 30 minutes, three times per week, over 8 weeks.

Resistance + BFR Group: Performs low-load resistance exercises with blood flow restriction applied to the thighs, also for 30 minutes per session, three times per week, over 8 weeks.

Control Group: Receives placebo treatment using a turned-off stimulation device with no active intervention during the 8-week period.

Primary outcomes

  1. Change in Muscle Mass

    Time frame: 2 month

    Assessed using Bioelectrical Impedance Analysis (BIA) to measure skeletal muscle mass.

    Evaluation is done pre- and post-intervention to detect changes in the Skeletal Muscle Index (SMI), based on EWGSOP2 criteria

Secondary outcomes

  1. Muscle Strength Handheld dynamometer (e.g., MicroFET)

    Time frame: 2 month

    Isometric knee extension strength

    Measurement: Pre- and post-intervention, using the highest or average value from 2-3 trials.

  2. Timed Up and Go (TUG) Test

    Time frame: 2 month

    Assesses eight domains of health-related quality of life, scored from 0 to 100. Administered before and after the intervention period

Sponsors and collaborators

Lead sponsor

Pharos University in Alexandria

Other

Registry information

Official study title

Effectiveness of Neuromuscular Electrical Stimulation Versus Low-load Resistance Training With Blood Flow Restriction in Elderly Individuals With Sarcopenia

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jun 10, 2025
Registry last updated
Jun 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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