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OpenTrials
Completed

NCT Number: NCT02132962

Sarcopenia and Cirrhosis

The study investigates the effect of aminoacid infusion on proteinturnover in muscle from cirrhosis subjects, compared to healthy controls.

The hypothesis is that aminoacid infusion can attenuate the increase in proteindegradation that follows cirrhosis.

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Key information

Conditions

Cirrhosis Fibrosis Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

30 year–70 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Rigshospitalet

Copenhagen, 2100, Denmark

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male subjects
  • Diagnosis of cirrhosis, Child-Pugh A, B, C.

Exclusion criteria

  • Acute illness within 3 weeks
  • Ascites collections within 10 days
  • Heart-, kidney, pulmonary disease. Cancer. Type 1 diabetes.
  • Active alkoholdrinking

Treatment and study plan

Amino acid infusion

Dietary Supplement

Bloodsamples, Biopsies.

Other

Primary outcomes

  1. Turnover of phenylalanine and tyrosine in skeletal muscle tissue during amino acid infusion. Inflammatory markers. Protein signaling cascade.

    Time frame: 24 weeks

    Using stable isotope tracer technique with infusion of phenylalanine and tyrosine tracer.

    Using ELISA technique. Using PCR and western blot technique.

Sponsors and collaborators

Lead sponsor

Rigshospitalet, Denmark

Other

Collaborators

  • Hvidovre University Hospital

Registry information

Important dates

Study start
2014
Primary completion
2015
First posted
May 7, 2014
Registry last updated
Oct 29, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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