Same-session MR-only Simulation and Treatment With MRI-guided Adaptive Palliative RadioTherapy

This proposed study is unique in that patients will not undergo computed tomography (CT) simulation at any point during their treatment course and will instead have same-session magnetic resonance (MR)-only simulation and treatment planning, on-table, using the adaptive radiotherapy (ART) workflow. In this manner, patients requiring urgent treatment could initiate treatment as early as the day of initial radiation oncology consultation.

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Key information

Conditions

Malignancy Cardiovascular Diseases Digestive System Diseases Gastrointestinal Bleeding Gastrointestinal Diseases Gastrointestinal Hemorrhage Hemoptysis Hemorrhage Lung Diseases Mediastinal Disease Mediastinal Diseases Metastasis Neoplasm Metastasis Neoplasms Neoplastic Processes Pathologic Processes Pathological Conditions, Signs and Symptoms Pelvic Bleeding Respiratory Tract Diseases Signs and Symptoms Signs and Symptoms, Respiratory Superior Vena Cava Syndrome Thoracic Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Washington University School of Medicine

St Louis, Missouri, 63110, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Diagnosis of malignancy (biopsy proven or high clinical suspicion with urgent/emergent clinical indications for palliative RT)
Requires delivery of palliative radiation therapy for the treatment of painful metastasis, hemoptysis, gastrointestinal bleeding, pelvic bleeding, or superior vena cava syndrome/bulky mediastinal disease.
At least 18 years of age.
Able to understand and willing to sign an IRB-approved written informed consent document.

Exclusion criteria

Pregnant. Patients of childbearing potential must have a negative pregnancy test within 14 days of study entry.
Medical contraindication to undergoing MR imaging.

Treatment and study plan

Volumetric MR imaging

Device

This will most frequently be supine with arms positioned so not in the way of treatment beams.

radiation therapy

Radiation

-Standard of care

Primary outcomes

Feasibility of Same-session MRI-only Simulation as Defined as More Than 70% of Patients Receiving at Least 70% of Their Scheduled Treatment Fractions on the First On-table Attempt for Each Respective Fraction.

Time frame: Completion of enrollment (approximately 29 months)

Sponsors and collaborators

Lead sponsor

Washington University School of Medicine

Other

Registry information

Official study title

Pilot Study of Same-session MR-only Simulation and Treatment With MRI-guided Adaptive Palliative RadioTherapy (MAP-RT)

Acronym: MAP-RT

Important dates

Study start: 2019
Primary completion: 2022
Study completion: 2022
First posted: Jan 31, 2019
Registry last updated: Jan 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed