SAMBA Trial: Towards a Paradigm Shift in Severe Asthma Management: Deep Analysis of the Effect of suBmaximal Aerobic Training

change from baseline Vo2Max at 3 months

A disease-specific health-related quality of life instrument that taps both physical and emotional impact of disease 32 items with 2-week recall, 4 different domains : Symptoms (11 items), Activity Limitation (12 items, 5 of which are individualized), Emotional Function (5 items), and Environmental Exposure (4 items) 7-point Likert scale (7 = not impaired at all - 1 = severely impaired) Scores range 1-7, with higher scores indicating better quality of life. Change from Baseline AQLQ at 3 months

Change from Baseline FEV1 at 3 months

change from baseline A questionnaire to determine if patient's asthma symptoms are well controlled. A score varying between 1 and 5 is assigned to each question. A score varying between 1 and 5 is assigned to each question. The higher the total score, the better the asthma is controlled From 1 to 14 : Uncontrolled asthma From 15 to 19 : Partially Controlled Asthma From 20 to 25 : Well controlled asthma

The questionnaire comprises seven questions for anxiety and seven questions for depression For each item, 4 response modes coded from 0 to 3. The anxiety and depression items are alternating. In addition, an alteration in the order of the ratings was carried out to avoid biases linked to their repetition.

An overall score is calculated by adding the 14 items but also 2 subtotals corresponding to the 2 subscales. The higher the scores, the higher the symptomatology.

From 0 to 7 : absence of anxiety disorders and depressive disorders From 8 to 10 : anxiety and depressive disorders suspected From 11 to 21 : severe anxiety and depressive disorders

change from baseline

change from baseline FENO at 3 months

FVC is the greatest total amount of air the patient can forcefully breathe out after breathing in as deeply as possible Change from Baseline FVC1 at 3 months

Change from baseline in amount of eosinophils and neutrophils in sputum

A simple questionnaire to measure the adequacy of asthma control and change in asthma control which occurs either spontaneously or as a result of treatment.

7 items; 1 week recall (for items on symptoms and rescue inhaler use) ACQ has a multidimensional construct assessing symptoms (5 items--self-administered) and rescue bronchodilator use (1 item-self-administered), and FEV1% (1 item) completed by clinic staff 7-point scale (0=no impairment, 6= maximum impairment for symptoms and rescue use; and 7 categories for FEV1%) Scores range between 0 (totally controlled) and 6 (severely uncontrolled). Change from Baseline ACQ at 3 months

change from baseline PMA at 3 months

Measured in KPa Change from baseline

Measured in KPa Change from baseline

measured using a dynamometer Change from baseline

volatils organics compounds change from baseline

measured using a Jamar dynamometer change from baseline

It is the total volume of air in the lungs after a maximal inspiration change from baseline TLC at 3 months

Measures the efficiency of the gas transfer characteristics of the lungs change from baseline DLCO at 3 months

Change from baseline PC20M at 3 months

change from baseline KCO at 3 months

The volume of air present in the lungs at the end of passive expiration Change from baseline FRC at 3 months

It is the amount of air remaining in the lungs after a maximal expiration Change from baseline RV at 3 months

Change from Baseline fall in FEV1 during ergospirometric measurement

Change from baseline sGaw at 3 months

Body composition evaluated through weight mesured in kg, BMI (kg/m²), Fat mass index and fat mass measured through DEXA scan.

We will use univariate and mutlivariate logistic regression analyses to assess the relationship between improvements in VO2max and a set of covariates individually or in combination.