Salt Sensitivity, Cardiovascular and Metabolic Disease

To identify the role of salt-sensitivity of blood pressure in the pathogenesis of hypertension.

Completed

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Key information

Conditions

Cardiovascular Diseases Angina Pectoris Brain Diseases Central Nervous System Diseases Cerebrovascular Accident Cerebrovascular Disorders Chest Pain Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Heart Diseases Heart Failure Heart Failure, Congestive Hypertension Infarction Ischemia Metabolic Diseases Myocardial Infarction Myocardial Ischemia Necrosis Nervous System Diseases Neurologic Manifestations Nutritional and Metabolic Diseases Pain Pathologic Processes Pathological Conditions, Signs and Symptoms Signs and Symptoms Stroke Vascular Diseases

Age range

Up to 100 year

Sex eligibility

Male

Study type

Observational

About this study

DESIGN NARRATIVE:

Approximately 498 of 750 normal and hypertensive subjects who were carefully characterized in terms of blood pressure response to salt loading and depletion in the late 1970s were re-examined to identify physiological factors contributing to salt-sensitivity of blood pressure. This helped to confirm preliminary observations suggesting that salt sensitivity in normotensive subjects predicted the subsequent development of hypertension with aging. In addition, longitudinal observations in hypertensive patients and in normotensives helped to determine whether salt-sensitivity or salt-resistance of blood pressure were associated with differences in the risk for development of specific forms of cardiovascular disease (stroke, angina, myocardial infarction, congestive heart failure), renal and metabolic (diabetes mellitus) disorders.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

No eligibility criteria

Sponsors and collaborators

Lead sponsor

Indiana University

Other

Collaborators

National Heart, Lung, and Blood Institute (NHLBI)

Registry information

Important dates

Study start: 1998
Study completion: 2001
First posted: May 26, 2000
Registry last updated: Dec 30, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed