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Completed

NCT Number: NCT02162706

Salivary Cortisol Measurements by Mass Spectrometry

Cortisol is a hormone critical for survival in times of stress. Currently most measurements are done with blood samples. The hypothesis of this study is cortisol measured from saliva using mass spectrometry can be used to replace measurements by blood.

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Key information

Conditions

Endocrine Disorders Endocrine System Diseases

Age range

3 year–17 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Lucile Packard Children's Hospital and Stanford Clinics

Stanford, California, 94305, United States

About this study

Cortisol levels change depending on the time of day. Salivary samples were collected from health controls at bedtime, midnight and first morning waking on two consecutive nights and salivary cortisol levels were measured using mass spectrometry. In a patients with possible endocrine disorders who were going through an adrenocortiotropin stimulation test for adrenal insufficiency, salivary cortisol was measured prior to giving cosyntropin and 30-40 minutes after cosyntropin.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Normal subjects
  • Subjects with possible endocrine disorder

Exclusion criteria

  • Tracheostomy or ventilator dependent
  • Gastrotomy tubed dependent or unable to eat/drink by mouth

Treatment and study plan

non intervention study

Other

Primary outcomes

  1. Salivary Cortisol

    Time frame: All collections are done within 48 hours

Sponsors and collaborators

Lead sponsor

Stanford University

Other

Registry information

Official study title

Pilot Study of Salivary Cortisol Measurements by Mass Spectrometry

Important dates

Study start
2013
Primary completion
2016
Study completion
2016
First posted
Jun 13, 2014
Registry last updated
Nov 13, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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