Salivary and Serum Levels of Chemerin and MMP-9 in Oral Premalignant and Malignant Lesions

45 individuals were subdivided into 3 groups, 15 patients with oral premalignant lesions, 15 patients with oral malignant lesions and 15 control individuals. Levels of chemerin and MMP-9 were evaluated in serum and saliva of these subjects utilizing the ELISA technique.

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Key information

Conditions

Precancerous Conditions Head and Neck Neoplasms Mouth Diseases Mouth Neoplasms Neoplasms Neoplasms by Site Oral Cancer Stomatognathic Diseases

Age range

40 year–50 year

Sex eligibility

All sexes

Study type

Observational

About this study

45 individuals were subdivided into 3 groups, 15 patients suffering from oral premalignant lesions, 15 patients suffering from oral malignant lesions and 15 individuals having age, gender and periodontal status matched with both patients groups acting as a control group. Serum and whole unstimulated saliva samples were collected from all the included groups in order to determine chemerin and MMP-9 in serum and saliva utilizing the ELISA technique.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients with oral premalignant lesions.
patients with oral malignant lesions.

Exclusion criteria

any systemic disease other than oral premalignant or malignant lesions. smokers. pregnant females. periodontal diseases.

Treatment and study plan

Primary outcomes

salivary levels of chemerin in patients with oral premalignant and malignant lesions.

Time frame: 1 day

Secondary outcomes

serum levels of chemerin in patients with oral premalignant and malignant lesions.

Time frame: 1 day
serum levels of MMP-9 in patients with oral premalignant and malignant lesions.

Time frame: morning visit
salivary levels of MMP-9 in patients with oral premalignant and malignant lesions.

Time frame: 1 day

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Salivary and Serum Levels of Chemerin and MMP-9 in Oral Precancer and Oral Squamous Cell Carcinoma.

Important dates

Study start: 2014
Primary completion: 2014
Study completion: 2014
First posted: Dec 23, 2014
Registry last updated: Feb 10, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed