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Completed

NCT Number: NCT03345745

Saliva Levels of S100A12, CRP, Fetuin-A in Periodontal Disease Patients

Hs-CRP, Fetuin-A and S100A12 are acute phase proteins associated with many systemic diseases and conditions. The aim of this study was to determine the clinical parameters and salivary Hs-CRP, Fetuin-A and S100A12 levels before and after non-surgical periodontal treatments in the patients with periodontal diseases.

A total of 54 subjects were divided in to three groups; periodontally healthy (n: 18), gingivitis (n: 18), chronic periodontitis (n: 18). Clinical periodontal parameters, salivary Hs-CRP, Fetuin-A and S100A12 levels and salivary flow rates were evaluated at baseline and a month after the treatments. Salivary Hs-CRP, Fetuin-A and S100A12 levels were assayed by ELISA.

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Key information

Conditions

Periodontal Inflammation Chronic Disease Chronic Periodontitis Disease Attributes Mouth Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Periodontal Diseases Periodontitis Stomatognathic Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Ordu University

Ordu, 52100, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

never-smokers no history of systemic disease no patients had been under periodontal therapy and medicine for at least 6 months before the study no pregnancy or lactation no alcohol or antioxidant vitamin consumption.

Exclusion criteria

-

Treatment and study plan

salivary samples

Diagnostic Test

Salivary Hs-CRP, Fetuin-A and S100A12 levels and salivary flow rates were evaluated at baseline and a month after the treatments

Primary outcomes

  1. Salivary acute phase proteins

    Time frame: Baseline - a month after the periodontal treatments

    Fetuin-A

  2. Salivary acute phase proteins

    Time frame: Baseline - a month after the periodontal treatments

    S100A12

  3. Salivary acute phase proteins

    Time frame: Baseline

    C-Reactive Protein

Secondary outcomes

  1. Evaluating periodontal health

    Time frame: Baseline - a month after the periodontal treatments

    plaque index

  2. Evaluating periodontal health

    Time frame: Baseline - a month after the periodontal treatments

    gingival index

  3. Evaluating periodontal health

    Time frame: Baseline

    probing depth

  4. Evaluating periodontal health

    Time frame: Baseline - a month after the periodontal treatments

    clinical attachment level

  5. Evaluating periodontal health

    Time frame: Baseline - a month after the periodontal treatments

    gingival bleeding on probing

Sponsors and collaborators

Lead sponsor

Ordu University

Other

Registry information

Official study title

The Short-Term Effects of Non-Surgical Periodontal Therapy on The Saliva Levels of S100A12, High-Sensitivity C-Reactive Protein and Fetuin-A in Patients With Gingivitis and Chronic Periodontitis

Important dates

Study start
2017
Primary completion
2017
Study completion
2017
First posted
Nov 17, 2017
Registry last updated
Nov 17, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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