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NCT Number: NCT07642791

Safety of Opportunistic Salpingectomy During Elective Laparoscopic Cholecystectomy.

The knowledge, coupled with epidemiological studies demonstrating lower ovarian cancer rates in women with a history of tubal sterilization has led to recommendations for opportunistic salpingectomy at the time of benign gynecological surgery. However, this recommendation was not explored in the setting of non-gynecological surgeries, of most if the surgery performed not in pelvis.

This study aims to evaluate the safety of performing opportunistic salpingectomy at the time of elective laparoscopic cholecystectomy in women aged 45 years or older. Of note, the only available prospective study from Austria evaluated feasibility of combined operation. By assessing complication rates and other perioperative outcomes, the study seeks to determine if this combined approach is a safe for opportunistic ovarian cancer prevention. Ultimately, this research may inform surgical practice and potentially reduce the incidence of ovarian cancer in this population.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Ovarian Cancer Adnexal Diseases Biliary Tract Diseases Cholecystolithiasis Cholelithiasis Digestive System Diseases Endocrine Gland Neoplasms Endocrine System Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Gallbladder Diseases Genital Diseases Genital Diseases, Female Genital Neoplasms, Female Gonadal Disorders Neoplasms Neoplasms by Site Ovarian Diseases Ovarian Neoplasms Urogenital Diseases Urogenital Neoplasms

Age range

45 year and older

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Division of Visceral Surgery and Transplantation , University Hospital Zurich

Zurich, 8091, Switzerland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Women aged 45 years or older.
  • No known history of ovarian or fallopian tube cancer.
  • Completed family planning.
  • Scheduled to undergo elective laparoscopic cholecystectomy for benign gallbladder disease.
  • Able to provide informed consent.
  • Willing to comply with study procedures and follow-up assessments.

Exclusion criteria

  • Previous abdominal Surgery or any inflammatory bowel disease.
  • Current pregnancy or breastfeeding (verbally asked).
  • Contraindications to laparoscopic surgery (e.g., severe cardiopulmonary disease, extensive prior abdominal surgery).
  • Any medical condition that, in the opinion of the investigator, would preclude safe participation in the study or interfere with follow-up.
  • Participation in another clinical trial that may confound the results of this study.

Treatment and study plan

Opportunistic salpingectomy

Procedure

Opportunistic salpingectomy at the time of elective laparoscopic cholecystectomy will be performed in study group, while the control group undergo cholecystectomy without salpingectomy.

Cholecystectomy

Procedure

Cholezystectomy as controll group

Primary outcomes

  1. Postoperative complications assesed with Comprehensive complication index.

    Time frame: within 6 weeks after surgery

    This will be the primary outcome measure, encompassing any complications assessed with Comprehensive Complication Index. The range between 0 and 100. The higher score means more complications.

Secondary outcomes

  1. Operating time

    Time frame: Operating time in minutes during surgical procedure

    Operating time measured in minutes from incision until skin stich

  2. Length of hospital stay

    Time frame: Length of hospital stay: The number of days patients remain hospitalized after surgery untill discharge assedd at discharge (assessed at around 5 days).

    Length of hospital stay calculated in days

Sponsors and collaborators

Lead sponsor

University of Zurich

Other

Registry information

Official study title

Safety of Opportunistic Salpingectomy During Elective Laparoscopic Cholecystectomy: A Randomized Controlled Trial

Important dates

Study start
2026
Primary completion
2028
Study completion
2029
First posted
Jun 11, 2026
Registry last updated
Jun 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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