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Completed

NCT Number: NCT03039829

Safety of Different Forms of Creatine

This study will aim to determine whether ingesting creatine nitrate (CrN) at higher doses will differentially affect hemodynamic variables compared to a placebo.

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Key information

Conditions

Nutritional Supplements

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

This study will examine the short-term (7 day) characteristics of ingesting creatine nitrate (CrN) compared to placebo on Chem-15 blood safety, heart rate, blood pressure, heart rate and blood pressure reactivity and self-reported side effects.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Apparently healthy
  • At least 6 months immediate prior history of resistance training including bench press and leg press or squat

Exclusion criteria

  • A history of treatment for metabolic disease (i.e., diabetes), hypertension, hypotension, thyroid disease, arrhythmias and/or cardiovascular disease
  • Use of prescription medication (birth control is allowed)
  • Pregnant or nursing or plan to become pregnant during the next month
  • Creatine or nitrate use in the last eight weeks
  • History of smoking
  • History of drinking (i.e., 12 drinks per week or more)
  • Use of nonsteroidal anti-inflammatory drugs (NSAIDs) including ibuprofen (Advil, Motrin, Nuprin, etc.), indomethacin (Indocin), naproxen (Aleve, Anaprox, Naprelan, Naprosyn), piroxicam (Feldene)

Treatment and study plan

Creatine nitrate, low dose

Dietary Supplement

Creatine nitrate at 3.0 grams (2.0 grams creatine, 1.0 gram nitrate, 3.0 grams dextrose)

Creatine nitrate, high dose

Dietary Supplement

Creatine nitrate at 6.0 grams (4.0 grams creatine, 2.0 grams nitrate)

Placebo

Dietary Supplement

Placebo at 6.0 grams (6.0 grams dextrose)

Primary outcomes

  1. Measuring the blood pressure response to creatine nitrate ingestion

    Time frame: 7 days

  2. Measuring the heart rate response to creatine nitrate ingestion

    Time frame: 7 days

Secondary outcomes

  1. Measuring a blood chemistry panel 15 response to creatine nitrate ingestion

    Time frame: 7 days

  2. Measuring the one Repetition Maximum (1 RM) muscle strength response to creatine nitrate ingestion

    Time frame: 7 days

  3. Measuring the repetitions to failure muscle endurance response to creatine nitrate ingestion

    Time frame: 7 days

  4. Measuring self-reported side effects of creatine nitrate ingestion

    Time frame: 7 days

Sponsors and collaborators

Lead sponsor

Texas A&M University

Other

Collaborators

  • Nutrabolt

Registry information

Official study title

Short-Term Safety and Dose Effects of Different Forms of Creatine

Acronym: NB9

Important dates

Study start
2016
Primary completion
2016
Study completion
2016
First posted
Feb 1, 2017
Registry last updated
Feb 1, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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