Skip to main content
OpenTrials
Completed

NCT Number: NCT00506805

Safety And Pharmacology Study Of SNX-5422 Mesylate In Subjects With Refractory Solid Tumor Malignancies

Hsp90 is a chemical in the body that is involved in promotion of cancer. SNX-5422 is an experimental drug that blocks Hsp90. It is being evaluated for safety and efficacy in patients with cancer.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Cancer Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

Pfizer Investigational Site, Scottsdale, Arizona, United States

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • >18 years old
  • histologically confirmed solid tumor malignancy
  • refractory to available therapy or for which no therapy is available
  • adequate organ function

Exclusion criteria

  • CNS malignancy
  • significant GI disease
  • at risk for prolonged QT interval

Treatment and study plan

SNX-5422

Drug

dose escalated, tablets every other day; undetermined duration until disease progression

Primary outcomes

  1. adverse events and other safety assessments

    Time frame: continuous

Secondary outcomes

  1. tumor response measured by X-rays or scans

    Time frame: after every 2 cycles

Sponsors and collaborators

Lead sponsor

Esanex Inc.

Industry

Collaborators

  • Pfizer
  • Serenex, Inc.

Registry information

Official study title

A Phase 1, Open-label, Dose-escalation Study Of The Safety And Pharmacokinetics Of SNX-5422 Mesylate In Subjects With Refractory Solid Tumor Malignancies Or Non-Hodgkin's Lymphoma

Important dates

Study start
2007
Primary completion
2010
Study completion
2010
First posted
Jul 25, 2007
Registry last updated
May 28, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.