Safety and Pharmacokinetics Study of Amlodipine 10mg and Candesartan 32mg

Inclusion criteria

• Male volunteers in the age between 20 and 55 years old(inclusive).
• Body weight >= 55kg and Body mass index (BMI) in the range of calculated IBW ±20%.
• Subjects without a hereditary problems or chronic desease.
• Subjects whose clinical laboratory test values are inside the accepted normal range.
• Understand the requirements of the study and voluntarily consent to participate in the study.

Exclusion criteria

• Subjects with a history of gastrointestinal diseases which might significantly change ADME of medicines.
• Systolic blood pressure range ≥150 mmHg or ≤ 100 mmHg or diastolic blood pressure range ≥ 95 mmHg or ≤ 60 mmHg.
• Subject with symptoms of acute disease within 14days prior to study medication dosing.
• Subjects with a history of clinically significant allergies of amlodipin or candesartan or CCB or other medicine (ex. aspirin or antibiotics).
• Subjects with galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption.
• Serum creatinine > 1.2mg/dL.
• smoking > 10 cigarettes/day.
• alcohol > 210g/week.
• Positive test results for drug test in urin or subject with history of substance abuse.
• Participation in any clinical investigation within 2 months prior to study medication dosing.
• Subjects with whole blood donation within 2 months, component blood donation within 1 month and blood transfusion within 1 month prior to study medication dosing.
• Subjects considered as unsuitable based on medical judgement by investigators.