Safety and Immunogenicity Study of Live Attenuated Vaccine Against Herpes Zoster in Chinese Adults Aged 50 Years and Older

Inclusion criteria

• Adults 50 years and older,no vaccine contraindications;
• Subject to comply with the requirements of clinical trial programs;
• No immune globulin vaccination history within a month, no vaccination history within 28 days;
• Axillary temperature ≤37.0 ℃;
• Patients with chronic diseases should be in stable ;
• Postmenopausal or female subjects is no longer the possibility of pregnancy, or subjects pregnancy test was negative and has no pregnancy planner during the clinical trial period;
• The value of blood routine (WBC, RBC, Hb) is normal , or abnormal but meaningless by clinicians judgment ;
• Alanine aminotransferase (ALT) values is normal, or abnormal but meaningless by clinicians judgment ;
• Renal function (serum urea nitrogen) is normal, or abnormal but meaningless by clinicians judgment.

Exclusion criteria

• Allergies, seizures, epilepsy, encephalopathy and other medical history or family history of mental illness;
• Subjects who is allergic to any element of the vaccine,and have a history of severe allergy to any vaccine;
• Subjects who is suffering from immune deficiency, receiving immunosuppressive therapy or immunocompromised due to HIV;
• Subjects who had a history of herpes zoster five years ago;
• Varicella or herpes zoster vaccination history;
• Pregnant or lactating women;
• Women who are planning a pregnancy in the near future;
• Any prior administration of vaccine in last 28 days or planned to vaccinate any vaccine during the observation period;
• Suffering from acute febrile diseases, and infectious diseases;
• Thrombocytopenia or other coagulation disorder history, which may cause subcutaneous taboo;
• Accept any other investigational drug users within two months;
• Subjects had high fever (axillary temperature ≥38.0 ℃) in the past three days ;
• The value of blood routine (WBC, RBC, Hb) is abnormal and meaning by clinicians judgment ;
• Alanine aminotransferase (ALT) values is abnormal and meaning by clinicians judgment ;
• Renal function (serum urea nitrogen) is abnormal and meaning by clinicians judgment.
• Blood pressure is abnormal after medication control;
• Known or suspected diseases including: respiratory diseases, acute infection or chronic disease , and cardiovascular disease, kidney disease, skin disorders in the acute phase;
• Any condition that in the opinion of the investigator, may interfere with the evaluation of study objectives.