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OpenTrials
Completed

NCT Number: NCT00940940

Safety and Immunogenicity of Zostavax Vaccine in Patients Undergoing Living Donor Kidney Transplantation

Varicella zoster virus is part of the herpesvirus group and causes chickenpox in exposed individuals. The majority of the population is seropositive for this virus. Reactivation of varicella zoster virus occurs in up to 30% of the general population over 60 years old.

Solid organ transplant recipients receive lifelong immunosuppression drugs and are at great risk of reactivation of all herpesviruses including the varicella zoster virus regardless of age. The vaccine has been shown to be effective in preventing shingles in the general population. The investigators' purpose is to determine how well the vaccine works in patients on renal replacement therapy and post-transplant.

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Key information

Conditions

Kidney Transplant

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

University of Alberta Hospital

Edmonton, Alberta, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18-65 years
  • Listed or will likely be listed for live donor kidney transplant within one month

Exclusion criteria

  • Previous receipt of Zostavax

Treatment and study plan

Zostavax (Live attenuated herpes zoster vaccine)

Biological

0.6 mL subcutaneous

Other names: Zostavax

Placebo vaccine

Biological

0.65 mL subcutaneous

Primary outcomes

  1. Immunogenicity

    Time frame: 6 months

Sponsors and collaborators

Lead sponsor

University of Alberta

Other

Registry information

Official study title

Safety and Immunogenicity of Live Attenuated Herpes Zoster Vaccine in Patients Undergoing Living Donor Kidney Transplantations

Important dates

Study start
2009
Primary completion
2013
Study completion
2013
First posted
Jul 17, 2009
Registry last updated
Jun 1, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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