S0309, Repository: Blood/Bone Marrow From Pts. With Myeloma, WM, Amyloidosis, or MGUS.

RATIONALE: Collecting and storing samples of blood and bone marrow from patients with cancer to study in the laboratory may help doctors find better ways to ways to treat the cancer.

PURPOSE: The purpose of this study is to collect and store blood and bone marrow samples from patients with multiple myeloma, smoldering myeloma, Waldenstrom's macroglobulinemia, amyloidosis, and monoclonal gammopathy of undetermined significance to be tested in the laboratory.

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Key information

Conditions

Multiple Myeloma Amyloidosis Blood Protein Disorders Cardiovascular Diseases Hematologic Diseases Hemic and Lymphatic Diseases Hemorrhagic Disorders Hemostatic Disorders Hypergammaglobulinemia Immune System Diseases Immunoglobulin Light-chain Amyloidosis Immunoproliferative Disorders Lymphatic Diseases Lymphoproliferative Disorders Metabolic Diseases Monoclonal Gammopathy of Undetermined Significance Neoplasms Neoplasms by Histologic Type Neoplasms, Plasma Cell Nutritional and Metabolic Diseases Paraproteinemias Precancerous Conditions Proteostasis Deficiencies Smoldering Multiple Myeloma Smoldering Myeloma Vascular Diseases Waldenstrom Macroglobulinemia Waldenstrom's Macroglobulinemia

Sex eligibility

All sexes

Study type

Observational

Primary location

Arkansas Cancer Research Center at University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States

About this study

OBJECTIVES:

Maintain and expand tissue repositories of myeloma specimens from uniformly treated Southwest Oncology Group (SWOG) patients with multiple myeloma, smoldering myeloma, Waldenstrom's macroglobulinemia, amyloidosis, or monoclonal gammopathy of undetermined significance.
Utilize scientific information generated from intergroup and collaborative studies to assist the SWOG Myeloma Committee in the development of new and more effective treatment regimens for these patients.

OUTLINE: Patients receive treatment as directed by the treatment protocols on which they are registered. Specimens of blood and/or marrow are submitted to the Myeloma Repository. The status of the patient (e.g., pre-study, post-remission, or relapse) will be recorded prior to specimen collection.

PROJECTED ACCRUAL: Not specified

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

DISEASE CHARACTERISTICS:

Diagnosis of 1 of the following:

Multiple myeloma
Smoldering myeloma
Waldenstrom's macroglobulinemia
Amyloidosis
Monoclonal gammopathy of undetermined significance
Must be currently registered on a Southwest Oncology Group-coordinated treatment study (SWOG or Intergroup)
Must have pretreatment specimens to submit to this study
No cytogenetic samples

PATIENT CHARACTERISTICS:

Not specified

PRIOR CONCURRENT THERAPY:

Not specified

Treatment and study plan

biologic sample preservation procedure

Other

Blood and 3-4 cc bone marrow aspirate collected at same time (in association with treatment protocols on which patient is registered)

Primary outcomes

Maintenance and expansion of tissue repositories of myeloma specimens from uniformly treated SWOG patients with multiple myeloma, smoldering myeloma, Waldenstrom's macroglobulinemia, amyloidosis, or monoclonal gammopathy of undetermined significance

Time frame: 7 years
Development of new and more effective treatment regimens for these patients using scientific information generated from intergroup and collaborative studies

Time frame: 7 years

Sponsors and collaborators

Lead sponsor

SWOG Cancer Research Network

Network

Collaborators

National Cancer Institute (NCI)

Registry information

Official study title

S0309, Myeloma Specimen Repository Protocol, Ancillary

Important dates

Study start: 2003
Primary completion: 2010
Study completion: 2010
First posted: Jun 12, 2009
Registry last updated: Apr 3, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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