Skip to main content
OpenTrials
Completed

NCT Number: NCT00442585

S(+)-Ibuprofen Effects on Asprin Treated Volunteers

The purpose of this clinical trial is to determine whether S(+)-ibuprofen affect the platelet inhibition under steady state acetylsalicylic acid conditions.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Drug Interactions

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

Department of Clinical Pharmacology, Medical University Vienna

Vienna, State of Vienna, 1090, Austria

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy caucasian volunteer
  • Must be able to swallow tablets

Exclusion criteria

  • Underlying diseases
  • Ulcus pepticum in history
  • Abuse of alcoholic beverages (40g/d)
  • Hypersensitivity to investigational medicinal products

Treatment and study plan

S(+)-ibuprofen

Drug

Primary outcomes

  1. Percentage of inhibition of TxB2 after 1, 3, 7 and 10 days

Secondary outcomes

  1. percentage of subjects with >90% inhibition of TxB2, CEPI-CT and CADP-CT measured by PAF100,

  2. prostacyclin metabolite

Sponsors and collaborators

Lead sponsor

Gebro Pharma GmbH

Industry

Registry information

Official study title

Double Blind, Randomised, Parallel Group, Placebo Controlled Clinical Trial of S(+)-Ibuprofen Effects on TxB2 Concentrations and Platelet Aggregation in Aspirin-treated Healthy Adult Volunteers

Important dates

Study start
2006
Study completion
2007
First posted
Mar 2, 2007
Registry last updated
Mar 13, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.