Rye Bread Trial; Antioxidative and Cholesterol Lowering Effects

The purpose of this study is to investigate the antioxidative effects of alkylresorcinols (AR), originating from the rye fiber, on serum LDL particles and the use of AR or it's metabolites as biomarkers for rye fiber intake and the effect of additional plants sterols, incorporated in the rye bread, on serum total and LDL cholesterol concentration.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Hypercholesterol

Age range

20 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Folkhälsan Research Center

Helsinki, 00290, Finland

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

healthy
volunteer
hemoglobin above 125 mmol/L in females, above 135 mmol/L in males

Exclusion criteria

taking drugs affecting plasma lipids or gastrointestinal track
severe illness
use of antibiotics within 3 months before entering the study
use of vitamin pills or fish oil 1 month before entering the study
pregnancy or lactating

Treatment and study plan

Rye-2008

Dietary Supplement

Sponsors and collaborators

Lead sponsor

University of Helsinki

Other

Collaborators

Fazer
Samfundet Folkhälsan
Sigrid Jusélius Foundation

Registry information

Official study title

Dietary Intervention Trial of Alkylresorcinols and Plant Sterols in High-Fibre Rye Bread and Their Effects on Serum Lipids in Normo- and Mildly Hypercholesterolemic Subjects

Acronym: Rye-2008

Important dates

Study start: 2008
Primary completion: 2009
Study completion: 2010
First posted: Mar 10, 2010
Registry last updated: Mar 10, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.