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Recruiting

NCT Number: NCT06773897

Rutgers University Study of the Genetics of Breast Cancer.

The goal of this observational study is to learn more about how genes impact the risk of breast cancer. Anyone 18 or older living in the US is eligible, and a diagnosis of cancer is NOT required. Study participation is online, and it takes about 20 minutes to complete health surveys and request a saliva collection kit sent through US mail. In return, study participants may opt to receive information about their genetic ancestry at no cost.

Recruiting

Interested in participating?

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Rutgers University

Piscataway, New Jersey, 08854, United States

Location status: Recruiting

Location contact

Tara Matise, Ph.D.

CONTACT

[email protected]

848-445-3125

About this study

This is an online research study to learn more about how genes affect the risk of breast cancer. No office visit is required and in return, participants may receive information about their genetic ancestry for free. BRCA1 and BRCA2 explain only about 25% of the genetic cause of breast cancer. This study will increase our understanding of the genetic basis of breast cancer, which is a crucial step in drug development to improve current treatment options. The study investigators seek a diverse population because men can also get breast cancer and diversity among participants maximizes the usefulness of the data. Participants will use our online study portal to answer questions about their health and provide their DNA via a saliva sample using a pre-paid mailer. Participation takes approximately 20 minutes. Participants will be invited to share data from their electronic health records, but this is not required for study participation. The study investigators keep participants engaged with short monthly newsletters.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age 18 years or older
  • currently living in the United States
  • able to understand and follow written instructions in English
  • have access to the internet and a computer, laptop, tablet or smart phone
  • willing to provide written informed consent for participation
  • willing to provide DNA via a saliva sample using a collection kit mailed to the study participant's home
  • willing to complete a survey with questions about health related to the study of breast cancer.

Exclusion criteria

  • Not able to meet or fulfill any of the inclusion criteria

Treatment and study plan

saliva sample

Genetic

Saliva sample is sent via prepaid US Mail for DNA extraction

Health Surveys

Other

Health surveys are filled out online in the study portal.

Primary outcomes

  1. Genetic risk variants associated with breast cancer

    Time frame: 2 years

    Genetic factors will be measured through whole exome sequencing along with genotyping of common variants, and then correlated with breast cancer and breast cancer subtype.

Study contacts

Contact information is provided by the study sponsor or research team.

Steve Buyske, Ph.D.

CONTACT

[email protected]

848-445-7680

Tara Matise, Ph.D.

CONTACT

[email protected]

848-445-3125

Sponsors and collaborators

Lead sponsor

Rutgers, The State University of New Jersey

Other

Collaborators

  • Regeneron Pharmaceuticals

Registry information

Official study title

The Rutgers University Genetics Coordinating Center Breast Cancer Study

Acronym: RUGCC-BC

Important dates

Study start
2024
Primary completion
2028
Study completion
2028
First posted
Jan 14, 2025
Registry last updated
May 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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