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Completed

NCT Number: NCT01406730

Running Effect on Cardiovascular and Muscular Parameters

The purpose of the study is to determine the effect of 16 weeks of running exercise on various parameters related to heart, vascular systems, blood, and muscle in untrained males 30-50 years old.

Further, the investigators assess which of the above mentioned parameters may explain the increase of running performance most accurate.

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Key information

Conditions

Males 30-50 Years Old Cardiomegaly Cardiovascular Diseases Healthy Heart Diseases Hypertrophy Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Untrained

Age range

30 year–50 year

Sex eligibility

Male

Study type

Interventional

Phase

Phase 3

Primary location

Departement of Radiology, University of Erlangen-Nurnberg, Erlangen, Germany

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Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • males
  • untrained (< 2 endurance exercise sessions/week)
  • 30-50 years old

Exclusion criteria

  • pathological changes of the heart
  • inflammable diseases
  • medication/diseases affecting cardiovascular system and muscle
  • very low physical capacity (< 100 Watt at ergometry)
  • obesity (BMI > 30 kg/m2)
  • more than 2 weeks of absence during the interventional period
  • more than 2 exercise session beside the intervention
  • contraindication related to MRI-assessment (i.e. claustrophobia, magnetizable intracorporal artefacts)

Treatment and study plan

Exercise

Other

16 week of periodized progressive running exercise 2-4 times/week

Primary outcomes

  1. myocardial mass/stroke volume

    Time frame: 4 month

    Atrial and ventricular volume and mass indexes were assessed by magnetic resonance imaging (MRI)

Secondary outcomes

  1. maximal oxygen uptake

    Time frame: 4 month

    maximal oxygen uptake during running

  2. Resting metabolic rate

    Time frame: 4 month

    Adaptation of resting metabolic rate to running exercise

  3. muscle strength/power

    Time frame: 4 month

    Isometric muscle strength of the leg extensors Leg power as assessed by counter movement jump

  4. myocardial volume

    Time frame: 4 month

    Functional and morphologic parameters of the heart as assessed by echocardiography

  5. Intima media thickness

    Time frame: 4 month

    Carotid intima media thickness by high-resolution ultrasound

Sponsors and collaborators

Lead sponsor

University of Erlangen-Nürnberg Medical School

Other

Collaborators

  • Institute of Physical Education and Sports Sciences
  • Klinikum Nürnberg
  • University of Erlangen-Nürnberg

Registry information

Official study title

Effect of 16 Weeks of Running Exercise on Parameters Related to the Cardiovascular System, Blood and Muscle in Untrained Males 30-50 Years Old. A Randomized Controlled Study

Important dates

Study start
2011
Primary completion
2012
Study completion
2012
First posted
Aug 1, 2011
Registry last updated
Aug 14, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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