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Completed

NCT Number: NCT01179230

Rubidium-82 Position Emission Computed Tomography (PET) Versus Gated, Rest / Stress Technetium 99-m SPECT

Many stress tests being done today have two parts, the stress test and the pictures of your heart. The investigators are comparing a newer technique to obtain the pictures (PET imaging) to the standard method (SPECT imaging). However, it is not known if the new test is better than the old test. It is important to have a standard to compare these tests to, and that is why people who will be getting a cardiac catheterization are being asked to participate. The information about your arteries from the cardiac catheterization will be used to judge which stress test is better. The investigators hypothesize that the newer method (PET imaging) will be more accurate than the old method (SPECT) in detecting heart disease.

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Key information

Conditions

Coronary Artery Disease Acute Coronary Syndrome Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Chest Pain Coronary Disease Heart Disease Heart Diseases Myocardial Ischemia Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms Vascular Diseases

Age range

50 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

The Heart Center, PC, Huntsville, Alabama, United States

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About this study

A SPECT rest image will be obtained using a technetium based isotope. On a separate day, a Rubidium rest PET image will be obtained prior to a Dipyridamole stress test. Subjects will receive both Rubidium and technetium isotopes following the Dipyridamole stress, and will undergo first PET imaging and later SPECT imaging following the stress test. Patients will then go for cardiac catheterization as clinically ordered by their physician.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • referred for clinical cardiac catheterization

Exclusion criteria

  • previous CABG
  • previous MI
  • Asthma or obstructive airway disease
  • Intolerance to Dipyridamole
  • Moderate to severe valvular disease
  • Cardiomyopathy - (ejection fraction less than 45%)

Treatment and study plan

SPECT imaging

Other

Dipyridamole stress testing 0.57 mg/kg

Other names: Pharmacological stress testing, Myocardial perfusion imaging, Persantine stress test

PET IMAGING

Other

Dipyridamole stress test 0.57 mg/kg with Rubidium PET images

Other names: PET perfusion images, Rb-92, PET persantine stress test

Primary outcomes

  1. Coronary Artery Disease

    Time frame: 30 days

Secondary outcomes

  1. Myocardial Ischemia

    Time frame: 30 days

Sponsors and collaborators

Lead sponsor

Hartford Hospital

Other

Collaborators

  • Bracco Diagnostics, Inc

Registry information

Official study title

A Prospective Comparison of Gated, Rest/Stress Rubidium-82 Position Emission Computed Tomography (PET) vs. Gated, Rest / Stress Technetium 99-m SPECT

Acronym: PETvsSPECT

Important dates

Study start
2005
Primary completion
2012
Study completion
2012
First posted
Aug 11, 2010
Registry last updated
Mar 23, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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