rTMS-induced Cumulative Pattern of sBDNF in Chronic Schizophrenia

This study aims at investigating the neuroplastic potential and the possible factors affecting rehabilitation in chronic schizophrenia patients on stable medication, by investigating the cumulative pattern of serum BDNF representing the neuroplasticity in the brain, through quantitative stimulus such as rTMS.

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Key information

Conditions

Schizophrenia Mental Disorders Schizophrenia Spectrum and Other Psychotic Disorders

Age range

25 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Jeonbuk Provincial Maeumsarang Hospital

Wanju, Jeollabuk-do, 565844, South Korea

About this study

Subjects who have been enrolled for this study will take baseline evaluation for sociodemographic data and serum level of BDNF, plasma Prolaction, and magnesium, etc. And then, weekday regular stimulation through rTMS will be applied on DLPFC of brain. After the completion of stimulation for 2 weeks, the change or response of serum BDNF will be analyzed and compared.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

duration of illness over 10 years
on stable medication, antipsychotics
no change on medication within at least 2 weeks
Diagnosis of Schizophrenia according to DSM-IV-TR

Exclusion criteria

left or both-handedness
anticonvulsant use
lorazepam equivalent over 3 mg

Treatment and study plan

CR Technology, TAMAS for repetitive TMS

Device

repetitive TMS, lef DLPFC, 20Hz, 100% of MEP, 2weeks

Primary outcomes

change from baseline of serum BDNF concentration

Time frame: baseline-1 week-2 week-4 week

Sponsors and collaborators

Lead sponsor

Jeonbuk Provincial Maeumsarang Hospital

Other

Registry information

Official study title

Short-Term Response of Serum Brain-Derived Neurotrophic Factor to Repetitive Transcranial Magnetic Stimulation in Patients With Chronic Schizophrenia

Important dates

Study start: 2011
Primary completion: 2011
Study completion: 2011
First posted: Sep 1, 2011
Registry last updated: Feb 18, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed