RSV Antibiotic Drivers And Resource-use

This retrospective, single-center study aimed to assess the clinical decision-making process regarding antibiotic prescription in children aged 1 to 24 months hospitalized with RSV-positive acute lower respiratory tract infections (ALRTI). The study was conducted at Dr. Behçet Uz Children's Hospital and covered four consecutive RSV seasons (April 2017 - April 2021). RSV infection was confirmed via multiplex PCR.

Clinical and laboratory variables potentially influencing antibiotic use included fever, respiratory distress, CRP levels, leukocyte count, and radiologic findings such as infiltrates on chest X-ray. The study also examined whether antibiotic selection (agent, timing, and duration) was associated with specific clinical profiles or severity indicators.

Hospitalization cost data were analyzed to estimate the economic burden of antibiotic use in RSV-positive patients. The study contributes to improved antimicrobial stewardship by identifying patterns of potentially unnecessary antibiotic prescriptions in viral respiratory infections.

Ethical approval was obtained from the local ethics committee (Approval No: 2021-634), and the study adhered to the principles of the Declaration of Helsinki.

Inclusion criteria

• Age between 1 and 24 months at the time of hospitalization
• Laboratory-confirmed RSV positivity via multiplex PCR
• Hospitalized for acute lower respiratory tract infection
• Complete hospitalization and clinical data available

Exclusion criteria

• Detection of additional respiratory pathogens on multiplex PCR
• Discharge against medical advice before treatment was completed
• Missing or incomplete key clinical, laboratory, or radiologic data
• ICU admission without full follow-up data