Rowing Away From Diabetes

Inclusion criteria

• Participant is willing and able to give informed consent for participation in the study.
• Participant is willing to allow their general practitioner to be informed of any incidental findings.
• Eligible men will be 45 to 65 years of age.
• Eligible women will be 45 to 65 years of age and will be postmenopausal, defined as no menstrual period in the last 12 months.
• Body mass index of 25 to 40 kg·m-2.
• Stable weight, defined as self-reported weight change of less than 5 kg in the last six months.
• Impaired glucose regulation, defined as impaired fasting glucose (fasting plasma glucose of 5.6 to 6.9 mmol·l-1), or impaired glucose tolerance (two-hour plasma glucose in the 75-g oral glucose tolerance test of 7.8 to 11.0 mmol·l-1), or haemoglobin A1C of 6.0% or greater, or type 2 diabetes (fasting plasma glucose of 7.0 mmol·l-1 or greater on two occasions).
• Volunteers with type 2 diabetes will either be treatment naïve or will have been taking a stable dose of metformin for at least four weeks prior to study entry.
• White European ethnicity. There are ethnic differences in cardiovascular disease risk and prevailing definitions of dyslipidaemia, insulin resistance and diabetes cannot account for these differences (Forouhi et al., Diabetologia, 2006, 49, 2580-8; Tillin et al., Journal of the American College of Cardiology, 2013, 61, 1777-86). Therefore, in order to make valid inferences, the investigators will only include white Europeans on this occasion.
• Little or no participation in exercise: eligible volunteers will not have been exercising two or more times per week for 20 minutes or longer for the last six months.

Exclusion criteria

• Volunteers with type 2 diabetes will be excluded if they are taking any form of diabetes medication other than metformin.
• Known cardiovascular disease.
• Symptoms of angina.
• Resting systole blood pressure ≥180 mm Hg or diastolic blood pressure ≥110 mm Hg.
• Statin use.
• Beta-blocker use.
• Verapamil use.
• Hormone replacement therapy.
• Any smoking in the last year.
• Any absolute contraindication to exercise testing.
• Abnormal exercise test.
• Inability to undertake an exercise programme for any reason.
• Participation in a research study involving an investigational produce in the past 12 weeks.
• Female volunteers who are pregnant, lactating or planning pregnancy during the course of the study. Pregnancy will be discussed during the consent procedure and the investigators will provide those in any doubt with a pregnancy test kit.
• Chronic kidney disease (EGFR of ≤30).
• Any metal implants.