Skip to main content
OpenTrials
Completed

NCT Number: NCT07192744

Rotigaptide in Endothelial Dysfunction?

Arterial occlusion can lead to tissue ischemia and, if prolonged, end organ infarction. Clinical and experimental data would suggest that restoration of blood flow might trigger additional injury beyond that induced by the ischemia alone, so called Ischemia Reperfusion (IR) injury. IR injury impairs endothelial function through a mechanism that may involve intercellular gap junctions. Rotigaptide (ZP-123) is an anti-arrhythmic drug promoting intercellular coupling by increasing gap junction conductance. We intend to test the hypothesis that rotigaptide protects the forearm arterial circulation from IR-induced endothelial dysfunction.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Ischaemic Heart Diseases Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Coronary Artery Disease Coronary Disease Heart Diseases Myocardial Ischemia Vascular Diseases

Age range

18 year–65 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

University of Edinburgh, 49 Little France Crescent

Edinburgh, EH16 4SB, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy males between 18-65 years of ages, non-smokers.

Exclusion criteria

  • Any concurrent illness or chronic medical condition. Concurrent use of vasoactive medication. Smoking history.

Treatment and study plan

Forearm Vascular Study

Procedure

Forearm blood flow measured by venous occlusion plethysmography during interarterial infusion of vasodilators (Ach). Venous blood sampling via cannula in antecubital fossa.

Primary outcomes

  1. Change in forearm blood flow after ischaemia reperfusion with or without co-infusion of Rotigaptide

    Time frame: 20 fixed timepoints throughout the study up to 4 hours

Sponsors and collaborators

Lead sponsor

University of Edinburgh

Other

Collaborators

  • University of Aarhus
  • University of Oxford

Registry information

Important dates

Study start
2008
Primary completion
2009
Study completion
2009
First posted
Sep 25, 2025
Registry last updated
Sep 25, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.