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Completed

NCT Number: NCT01334619

Ropivacaine Volume for Ultrasound-guided Retrograde Infraclavicular Brachial Plexus Block

The retrograde infraclavicular brachial plexus block has been proved an effective and safe approach. Realtime ultrasound guide will facilitate a successful peripheral nerve block. The purpose of this study was to determine the medium effective volume required to produce an effective retrograde infraclavicular block using an ultrasound (US)-guided technique.

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Key information

Conditions

Upper Extremity Injury Trauma

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Beijing jishuitan hospital

Beijing, 100035, China

About this study

Thirty adults undergoing elective upper limb surgery received an US-guided retrograde infraclavicular block. The initial concentration of 0.5% ropivacaine injected was 30 ml, which was subsequently varied at a ratio of 1: 1.2 for each consecutive patient according to the response of the previous patient. The medium effective volume (EV50) was determined using the Dixon and Massey up-and-down method. The effective volume in 95% of patients (EV95) was calculated using probit regression.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Elected upper extremity operations
  • BMI 17~30kg/m2
  • ASA I/II

Exclusion criteria

  • Infection at injection site
  • Sepsis
  • Coagulation Dysfunction
  • Phrenic nerve palsy
  • Pneumothorax
  • Recurrent laryngeal nerve palsy
  • Clavicle fracture combined with nerve damage

Treatment and study plan

appropriate volume of 0.5% ropivacaine

Procedure

initial concentration: 30 ml, subsequently varied at a ratio of 1: 1.2 for each consecutive patient according to the response of the previous patient, until 5 up-and-down cycles completed.

Other names: Naropin

Primary outcomes

  1. VAS of brachial plexus innervated area

    Time frame: 20 minutes

    effect and side effects of the present block approach for brachial plexus.

Secondary outcomes

  1. medium effective ropivacaine volume

    Time frame: about 2 months

    The initial concentration of 0.5% ropivacaine injected was 30 ml, which was subsequently varied at a ratio of 1: 1.2 for each consecutive patient according to the response of the previous patient. The medium effective volume (EV50) was determined using the Dixon and Massey up-and-down method. EV95 was calculated using probit regression.

Sponsors and collaborators

Lead sponsor

Beijing Jishuitan Hospital

Other

Registry information

Important dates

Study start
2010
Primary completion
2010
Study completion
2010
First posted
Apr 13, 2011
Registry last updated
Apr 13, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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