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Completed

NCT Number: NCT07744685

Root Shortening With Three Methods of Upper Front Teeth Retraction

External apical root resorption is a possible side effect of fixed orthodontic treatment, particularly in the upper front teeth. This randomized clinical trial was conducted to compare the amount and timing of root resorption associated with three different methods of retracting the upper anterior teeth using miniscrew anchorage. Sixty adult patients with Class II Division 1 malocclusion who required extraction of the upper first premolars were randomly allocated to one of three groups: a bidimensional bracket group, a hybrid dual-section archwire group, or a conventional sliding mechanics group. In all groups, the six upper anterior teeth were retracted together with the support of orthodontic miniscrews. Panoramic radiographs were obtained before treatment, after completion of leveling and alignment, and after completion of en-masse retraction. Root and crown lengths were measured on these radiographs to estimate external apical root resorption during the leveling and alignment phase, during the retraction phase, and over the complete observation period. The study also compared the pattern of resorption among the upper canines, lateral incisors, and central incisors.

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Key information

Age range

18 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Dentistry

Damascus, DM20AM19, Syria

About this study

Orthodontic camouflage treatment of adult patients with Class II Division 1 malocclusion frequently involves extraction of the maxillary first premolars followed by retraction of the upper anterior teeth. Temporary orthodontic miniscrews can provide skeletal anchorage during this stage and allow the six maxillary anterior teeth to be retracted together as one unit. Although these mechanics are widely used, the anterior teeth remain exposed to orthodontic forces during both the initial leveling and alignment phase and the subsequent retraction phase. External apical root resorption is therefore an important biological safety outcome that should be evaluated throughout treatment rather than only after space closure has been completed.

This single-center, three-arm, parallel-group randomized clinical trial was conducted at the Department of Orthodontics, Faculty of Dentistry, Damascus University. Sixty adult patients with Class II Division 1 malocclusion who required extraction-based orthodontic camouflage treatment were allocated equally to one of three treatment groups: a bidimensional bracket group, a hybrid dual-section archwire group, or a conventional sliding mechanics group.

The three approaches differed in the relationship between the anterior brackets and the working archwire. The bidimensional approach used smaller anterior bracket slots with larger posterior slots. The hybrid dual-section approach used a customized archwire with different anterior and posterior cross-sections, while the conventional group used a continuous archwire with a uniform cross-section. These mechanical differences may influence archwire engagement, force expression, and the distribution of forces applied to the roots of the maxillary anterior teeth. Their possible effect on external apical root resorption therefore required direct clinical comparison.

All participants underwent bilateral extraction of the maxillary first premolars, fixed-appliance leveling and alignment, and miniscrew-supported en-masse retraction of the six maxillary anterior teeth. The same general treatment stages and skeletal anchorage concept were used in all groups, while the bracket-slot and archwire configurations varied according to group allocation. Retraction continued until an acceptable overjet and a Class I canine relationship were achieved. Participants were reviewed regularly throughout treatment, and miniscrew-related or other treatment-associated adverse events were recorded.

Digital panoramic radiographs were obtained before orthodontic treatment, at the end of leveling and alignment immediately before retraction, and after completion of en-masse retraction. The maxillary central incisors, lateral incisors, and canines on both sides were assessed individually. Crown length was used as a stable reference to correct for differences in radiographic magnification between time points.

The study was designed to determine whether the three treatment approaches were associated with different amounts of external apical root resorption and to identify the treatment phase during which root shortening occurred. Resorption was therefore evaluated separately during leveling and alignment, during en-masse retraction, and across the complete observation period. This phase-specific design was intended to avoid attributing all root changes detected at the end of retraction to the retraction mechanics alone.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18-30 years.
  • Class II Division 1 dental malocclusion according to Angle classification
  • Mild-to-moderate skeletal Class II discrepancy, with an ANB angle greater than 4° and not exceeding 7°.
  • Overjet ranging from 5 to 9 mm.
  • Presence of all six maxillary anterior teeth.
  • Maxillary anterior teeth fully erupted and with complete root formation.

Exclusion criteria

  • Patients with previous orthodontic treatment.
  • Missing permanent maxillary teeth.
  • Active periodontal disease.
  • History of trauma to any maxillary anterior tooth.
  • Previous endodontic treatment of any maxillary anterior tooth.
  • Periapical pathology involving any maxillary anterior tooth.
  • Extensive coronal restorations that could interfere with crown-length measurement.
  • Radiographic evidence of pre-existing root resorption before orthodontic treatment.

Treatment and study plan

Bidimensional Bracket System

Procedure

Fixed orthodontic treatment will be performed using 0.018-inch slot brackets from canine to canine and 0.022-inch slot brackets on the posterior teeth. After leveling and alignment, en-masse retraction will be performed on a 0.018 × 0.025-inch stainless-steel archwire using bilateral orthodontic miniscrews and nickel-titanium closed-coil springs delivering 250 g of force per side.

Hybrid Dual-Section Archwire

Procedure

Fixed orthodontic treatment will be performed using 0.022-inch slot brackets. En-masse retraction will be carried out using a customized stainless-steel archwire consisting of a 0.019 × 0.025-inch anterior section and 0.016 × 0.022-inch posterior sections, with the transitions located distal to the maxillary canines. Bilateral orthodontic miniscrews and nickel-titanium closed-coil springs delivering 250 g per side will be used.

Conventional Sliding Mechanics

Procedure

Fixed orthodontic treatment will be performed using 0.022-inch slot brackets. En-masse retraction will be carried out on a continuous 0.019 × 0.025-inch stainless-steel archwire using bilateral orthodontic miniscrews and nickel-titanium closed-coil springs delivering 250 g of force per side.

Primary outcomes

  1. External Apical Root Resorption of the Maxillary Anterior Teeth

    Time frame: Time 0: before the initiation of orthodontic treatment; Time 1: after the leveling and alignment stage, which occurs within an average of four months, Time Final: after the en-masse retraction stage, which occurs wihtin an averag 12 months.

    External apical root resorption was assessed separately for the six maxillary anterior teeth by measuring changes in corrected root length on digital panoramic radiographs using ImageJ software. Crown length was used as a stable reference to correct for differences in radiographic magnification. Root resorption was expressed in millimeters, and the total amount was calculated directly from the initial and final radiographs rather than by adding the interval measurements.

Sponsors and collaborators

Lead sponsor

Damascus University

Other

Registry information

Official study title

External Apical Root Resorption in Three Miniscrew-Supported Maxillary En-Masse Retraction Mechanics: A Randomized Controlled Trial

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Aug 4, 2026
Registry last updated
Aug 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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