Role of Stress CMR in Predicting Adverse Clinical Events in Patients With Known or Suspected IHD

The investigators plan to use retrospective data to assess heart function and structure abnormalities through the use of an approved vasodilating agent for stress cardiac MRI tests. The investigators are interested in how these MRI findings relate to long-term prognosis in people who are at risk for cardiac disease.

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Key information

Conditions

Coronary Artery Disease Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Coronary Disease Heart Diseases Myocardial Ischemia Vascular Diseases

Age range

21 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Brigham and Women's Hospital, Boston, Massachusetts, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age >/= 21 years old
No contraindications for cardiac MRI (by renal function or metallic hazards)

Treatment and study plan

Primary outcomes

A composite outcome measure consisting of cardiovascular mortality and nonfatal MI after index CMR.

Time frame: target follow up of at least 4 years

"Myocardial infarction" will be defined as hospital admission for acute coronary syndrome (defined by positive serum troponin level with documented electrocardiographic changes, clinical syndrome, or need for percutaneous or surgical revascularization).

Secondary outcomes

A composite outcome measure consisting of cardiovascular mortality, nonfatal MI, hospitalization for unstable angina or congestive heart failure, and late unplanned coronary bypass surgery at at least 6 months after index CMR.

Time frame: target follow up of at least 4 years

"Heart failure hospitalization" will be defined as any hospitalization for signs and symptoms of volume overload or dyspnea requiring diuretic therapy regardless of LV ejection fraction.

Sponsors and collaborators

Lead sponsor

Brigham and Women's Hospital

Other

Registry information

Official study title

Role of Stress CMR in Predicting Adverse Clinical Events in Patients With Known or Suspected Ischemic Heart Disease

Important dates

Study start: 2012
Primary completion: 2016
Study completion: 2018
First posted: Apr 1, 2013
Registry last updated: Nov 6, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed