Role of Proteomics and Metallomics in Cerebral Vasospasm Following Subarachnoid Hemorrhage

The purpose of this study is to determine the role of Proteomics and Metallomics in Cerebral Vasospasm following Subarachnoid Hemorrhage

Completed

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Key information

Conditions

Subarachnoid Hemorrhage Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebral Vasospasm Cerebrovascular Disorders Hemorrhage Hydrocephalus Intracranial Hemorrhages Nervous System Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Vascular Diseases Vasospasm, Intracranial

Age range

18 year–89 year

Sex eligibility

All sexes

Study type

Observational

Primary location

State University of New York Upstate Medical University

Syracuse, New York, 13210, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Non traumatic SAH documented by CT scan
Patient with SAH who would need external ventricular drain (EVD) for the management of hydrocephalus
Patients with normal pressure Hydrocephalus that require an external drain
Control (non - hemorrhagic) group - CSF collected from patients with posterior fossa tumor or stroke with EVD in place for the management of hydrocephalus.

Exclusion criteria

Recent infection within last 1 month of presentation- can increase inflammatory markers
Recent surgery or acute myocardial infarction within last 1 month of presentation
Age > 89 years or < 18 years

Treatment and study plan

Primary outcomes

Protein identification and concentration

Time frame: For the duration of CSF drainage, or until the 21st day after admission.
Metal ion identification and concentration

Time frame: For the duration of CSF drainage, or until the 21st day after admission.

Sponsors and collaborators

Lead sponsor

State University of New York - Upstate Medical University

Other

Registry information

Important dates

Study start: 2011
Primary completion: 2013
Study completion: 2013
First posted: Feb 26, 2013
Registry last updated: Nov 20, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed