Role of Prohepcidin in Uremic Patients

The investigators aimed to study the effect of prohepcidin levels on hematologic parameters and inflammatory markers in non-diabetic uremic patients. The investigators selected three groups of patients: Hemodialysis group, peritoneal dialysis group and the group with stage 4 chronic kidney disease. A control group was formed from healthy volunteers also. Each group has been planned to be formed of about 25 patients. Diabetic patients were excluded. Prohepcidin, hsCRP, IL-6, fibrinogen have been planned to be studied besides other routine biochemical analysis including hematological ones.

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Key information

Conditions

Inflammation Chronic Disease Chronic Kidney Disease Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Uremia Urogenital Diseases Urologic Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Haseki Training and Research Hospital

Istanbul, 34390, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

hemodialysis and peritoneal dialysis patients who had been on dialysis therapy for more than 3 months,
age between 18-80 years,
patients with creatinine clearance between 15-30 ml/min.

Exclusion criteria

age less than 18 or more than 80,
diabetic patients,
current active infectious or inflammatory disease.

Treatment and study plan

Primary outcomes

prohepcidin level

Time frame: Six months

Prohepcidin levels will be compared with other inflammatory markers.

Secondary outcomes

Anemia and inflammatory markers

Time frame: Six months

Correlations of prohepcidin levels with anemia and inflamatory markers

Sponsors and collaborators

Lead sponsor

Haseki Training and Research Hospital

Other

Registry information

Official study title

The Relationship of Prohepcidin Levels With Anemia and Inflammatory Markers in Non-diabetic Uremic Patients: A Controlled Study

Important dates

Study start: 2010
Primary completion: 2011
Study completion: 2011
First posted: Nov 28, 2012
Registry last updated: Nov 28, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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