Role of PET/MRI in Head and Neck Cancer

Study aim was to investigate the diagnostic role of Positron Emission Tomography / Magnetic Resonance Imaging (PET/MRI) in head and neck cancer.

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Key information

Conditions

Head and Neck Cancer Benign Neoplasm Head and Neck Neoplasms Malignant Neoplasm Neoplasms Neoplasms by Site

Age range

41 year–88 year

Sex eligibility

All sexes

Study type

Observational

About this study

This study was assessed the role of Diffusion weighted imaging (DWI) in discriminating between benign and malignant lesions in Head and neck cancer as well as studying the relationship between glucose metabolism (18F-FDG) and Apparent diffusion coefficient (ADC) for better tumor assessment.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Proved Head and neck cancer
Underwent PET/CT and PET/MRI
Lymph nodes due to primary Head and neck cancer.

For healthy subject:

No previous history of malignancy.
no inflammation or infection in the neck region.
lymph node size <10mm.

Exclusion criteria

patients treated before by radiotherapy / chemoradiotherapy
patients underwent surgery
artifacts

Treatment and study plan

Radiotherapy

Radiation

Patients have received radiotherapy as a treatment modality for Head and neck cancer

Primary outcomes

Difference in Apparent diffusion coefficient value between benign and malignant lesions

Time frame: Baseline

Apparent diffusion coefficient (ADC) was measured from benign and malignant lymph nodes by drawing region of interest (ROI) on the most homogeneous and most solid part in the target lymph node. Higher ADC value in Benign lymph node means that there are more water molecules movement inside the lymph node, more water molecules movement resulting in higher Apparent diffusion coefficient value. in malignant nodes and due to more tumor tissue, the result is to have lower water molecules motion so, lower ADC value.

Sponsors and collaborators

Lead sponsor

University of Pecs

Other

Registry information

Official study title

PET/CT and PET/MRI Based Treatment Modalities in the Modern Oncology

Important dates

Study start: 2016
Primary completion: 2019
Study completion: 2020
First posted: Apr 24, 2020
Registry last updated: Dec 29, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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