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NCT Number: NCT05539508

Role of Peripheral Vision in Scene Perception (PERISCE)

Despite its low spatial resolution, peripheral vision is very useful for rapidly categorizing a visual scene. Low spatial frequencies of a visual stimulus available in peripheral vision would allow a coarse categorization of the scene and objects (deciding, for example, whether it is an urban or natural landscape). This first representation would then trigger predictive mechanisms which would subsequently guide a more detailed visual analysis in central vision. The psychophysical studies that the investigators have already conducted in this scientific context has been carried out under normal vision conditions. The objective of this project is to study the influence of peripheral vision on central vision with an original approach: What are the consequences of a loss of peripheral vision on the processing performed in central vision? The project will concern patients with glaucoma. This ophthalmic pathology particularly affects the peripheral retina and thus represents a good pathological cognitive model of a visual recognition system in which peripheral vision is less important. The investigators will conduct psychophysical studies with glaucomatous patients and healthy volunteers with normal vision. All participants will be required to perform a short experiment on a computer (15 minutes) where they will look at different photographs of scenes of different luminance and spatial frequencies. Participants will have to perform various tasks on these images using the keys on the keyboard.

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Key information

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

For patients :

  • between 18 and 80 years old
  • stable bilateral primary open angle glaucoma (POAG)
  • visual acuity > 5/10 for distant vision for the eye tested
  • peripheral visual field defect on the eye tested measured through a Humphrey Visual Field Analyzer

For healthy volunteers :

  • between 18 and 80 years old
  • visual acuity > 5/10
  • absence of ophthalmologic disease other than Glaucoma (age-related macular degeneration, cataract except for uncomplicated cataract surgery, amblyopia, optic neuropathy, diabetic retinopathy …)

Exclusion criteria

  • ophthalmologic disease other than Glaucoma (age-related macular degeneration, cataract except for uncomplicated cataract surgery, amblyopia, optic neuropathy, diabetic retinopathy …)
  • treated with medication that might compromise sustained attention (benzodiazepine, narcoleptics)

Treatment and study plan

Psychophysical evaluation

Behavioral

All participants will be required to perform a short experiment on a computer (15 minutes) where they will look at different photographs of scenes of different luminance and spatial frequencies. They will have to perform various tasks on these images using the keys on the keyboard.

Primary outcomes

  1. Psychophysical measure : Percentage of correct response

    Time frame: Through study completion of 45 months

    Measure calculated by the comparison between the expected response and the response provided by the participant for each trial of the experiment

  2. Psychophysical measure : Mean reaction time in milliseconds

    Time frame: Through study completion of 45 months

    Measure calculated by averaging the time in milliseconds taken by the participant to provide the response for each trial of the experiment

Study contacts

Contact information is provided by the study sponsor or research team.

Carole Peyrin, PhD

CONTACT

[email protected]

04 76 82 58 79

Sponsors and collaborators

Lead sponsor

University Hospital, Grenoble

Other

Registry information

Official study title

Role of Peripheral Vision in Scene Perception

Acronym: PERISCE

Important dates

Study start
2022
Primary completion
2026
Study completion
2027
First posted
Sep 14, 2022
Registry last updated
Sep 14, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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