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Completed

NCT Number: NCT06437717

Role of Nanoemulsified Sesame Oil in Post-operative Care After Endoscopic Sinus Surgery

The goal of our thesis is to design, develop and characterize a novel thermodynamically stable NE by spontaneous method intended for topical use. Subsequently, appraisal of nanoemulsified sesame oil formulation has been performed on the post-operative symptoms in CRS patients who have undergone ESS (endoscopic sinus surgery) combined with different types of nasal irrigation which may affect formulation efficacy.

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Key information

Conditions

Chronic Rhinosinusitis (Diagnosis) Disease Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Mansoura University

Al Mansurah, Dakahliya, 35511, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient age between 18 and 60 years old.
  • chronic rhinosinusitis patients who have undergone endoscopic sinus surgery.

Exclusion criteria

  • Patients with history of allergy for sesame seed derivatives.
  • Patients with chronic diseases which affecting the process of healing (uncontrolled DM, renal failure and hepatic failure).
  • Patients with nasal granulomas.
  • Patients with invasive fungal rhinosinusitis.
  • Smokers.
  • Patients with history of radio and/or chemotherapy exposure.
  • Patients with systemic diseases affecting integrity of nasal mucosa (e.g. CF, scleroderma, Sjogren syndrome …).

Treatment and study plan

application of different topical nasal solutions

Other

each group receives a type of nasal solution to detect if there is a difference in the outcomes in chronic rhinosinusitis patients

Primary outcomes

  1. Sinonasal Outcome Test 22 (SNOT-22)

    Time frame: weekly for three months

  2. Lund-Kennedy endoscopic grading system

    Time frame: once monthly for three months

Sponsors and collaborators

Lead sponsor

Mansoura University

Other

Registry information

Important dates

Study start
2022
Primary completion
2023
Study completion
2024
First posted
May 31, 2024
Registry last updated
Sep 12, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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