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Completed

NCT Number: NCT04902001

Role of Mechanical Load on Metabolic Exercise Adaptations in Response to Weight Loss in Obese Adolescents: The POWELL Study

While interdisciplinary weight loss intervention have been shown successful among adolescents with obesity, a weight regain is most of the time observed within the following weeks or months. The aim of the present project will be to better identify the independent role played by both the metabolic and mechanical load and their modification during weight loss, on the energy expenditure and energy metabolism of adolescents with obesity.

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Key information

Conditions

Pediatric Obesity Body Weight Body Weight Changes Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms Weight Loss

Age range

12 year–16 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHU clermont-ferrand

Clermont-Ferrand, France

About this study

A total of 28 adolescents with obesity will be recruited from our local inpatient pediatric obesity centers. Before their weight loss intervention the adolescents will complete two experimental visits. During the first visit, anthropometric and body composition measurements will be performed. Then the participants will be asked to complete a walking exercise on a treadmill during the second visit. Their energy expenditure and substrate oxidation will be assessed by indirect calorimetry. They will have to walk at 5 different walking speeds. Then, they will follow a 12-week weight loss intervention. By the end of this intervention, their body composition will be assessed and they will be asked to perform the same walking exercise. On a separate occasion (randomly assigned) they will have to repeat this walking exercise while carrying a load corresponding of their weight loss.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • being aged 12-16 years old
  • no contraindication to physical exercise
  • no cardiovascular disease
  • BMI above the 97th percentile
  • candidate to a weight loss intervention

Exclusion criteria

  • surgery and medical conditions preventing them to perform the intervention
  • Weight loss during the previous 6 months
  • medication that could interfere with energy metabolism.
  • pregnancy
  • regular tobacco and alcool use

Treatment and study plan

Multidisciplinary weight loss

Behavioral

The adolescents will follow a 12-week intervention combining nutritional education, physical activity 3 times per week and psychological supports.

Primary outcomes

  1. Change in Energy Expenditure between before and after weight loss

    Time frame: before and after the 12-week weight loss

    amount of energy expended during the walking tests, measured using indirect calorimetry

Secondary outcomes

  1. change in lipid oxidation between before and after weight loss

    Time frame: before and after the 12-week weight loss

    amount of lipids oxidized during the walking tests, measured using indirect calorimetry

  2. change in Fat mass between before and after weight loss

    Time frame: before and after the 12-week weight loss

    The amount of body fat will be assessed by dual energy X-ray absorptiometry

  3. change physical activity preferences between before and after weight loss

    Time frame: before and after the 12-week weight loss intervention

    Children will be asked to indicate their prefered physical activties and sedenatry behaviors on a computer task using visual analog scale (from 0 to 150 mm)

  4. Change in Energy Expenditure between the unloaded and loaded walking test

    Time frame: after the 12_week weight loss

    amount of energy expended during the walking tests, measured using indirect calorimetry

  5. Change in lipid oxidation between the unloaded and loaded walking test

    Time frame: after the 12_week weight loss

    amount of lipids oxidized during the walking tests, measured using indirect calorimetry

Sponsors and collaborators

Lead sponsor

University Hospital, Clermont-Ferrand

Other

Registry information

Acronym: POWELL

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
May 26, 2021
Registry last updated
Jun 3, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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