Cyanoacrylate Glue Versus Absorbable Gelatin Sponge for Gastric Varices
NCT07699354
Digestive System Diseases, Esophageal Diseases
Toronto, Ontario, Canada
View Trial DetailsNCT Number: NCT06707298
Esophageal varices are one of the major complications of liver cirrhosis.Accurate grading of these varices is essential for effective management . Traditionally, esophagogastroduodenoscopy is the gold standard for diagnosing and grading esophageal varices,Multi detector computed tomography (MDCT) has emerged as a non-invasive alternative for evaluating esophageal varices.it particularly appealing for patients who contraindicated to endoscopy .
Trial opening soon.
Get Notified18 year–80 year
All sexes
Observational
Esophageal varices are one of the major complications of liver cirrhosis, with an estimated prevalence of approximately 80% with decompensated patients and 50% in compensated cirrhosis, pose a significant risk of life-threatening of bleeding due to portal hypertension. Accurate grading of these varices is essential for effective management . Traditionally, esophagogastroduodenoscopy (EGD) is the gold standard for diagnosing and grading esophageal varices . IT provides direct visualization, allowing for detailed assessment of variceal size and other risk factors for bleeding . However, it is an invasive procedure that requires sedation and carries some risks, such as bleeding or perforation .
Multi detector computed tomography (MDCT) has emerged as a non-invasive alternative for evaluating esophageal varices. It offers detailed cross-sectional images and is widely available, providing a broader assessment of abdominal pathology. Its non-invasive nature makes it particularly appealing for patients who contraindicated to endoscopy .
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
-Cirrhotic patients with portal hypertension undergoing upper GI endoscopy.
Exclusion criteria
-Contraindication to contrast:( severe renal insufficiency, allergy to contrast agents).
-Previous history of upper GI endoscopy with intervention (band ligation or sclerotherapy).-
Time frame: Baseline
Agreement between MDCT and endoscopy in the grading of esophageal varices
Time frame: Baseline
Assessment of the presence of complications or additional findings (e.g., portal vein thrombosis,Liver pathology) and other complication related to portal hypertension as ascites or splenomegaly on MDCT.
Assiut University
Other
The Role of Multidetector Computed Tomography(MDCT) in Grading of Oesophageal Varices in Cirrhotic Patients in Comparison to Endoscopy
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