Role of Low Carbohydrate Nutrient in Healing of Infected Diabetic Foot

A low-carbohydrate diet, when combined with standard wound care and diabetes management, appears to accelerate the healing of infected diabetic foot, improve blood glucose control, reduce systemic inflammation and promoting overall patient recovery. This approach could be considered a beneficial adjunct therapy in the treatment of diabetic foot infections.

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Key information

Conditions

Carbohydrate Ingestion Cardiovascular Diseases Diabetes Complications Diabetes Mellitus Diabetic Angiopathies Diabetic Foot Diabetic Neuropathies Endocrine System Diseases Foot Ulcer Leg Ulcer Skin Diseases Skin Ulcer Skin and Connective Tissue Diseases Vascular Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Aswan University Hospital

Aswān, Egypt

About this study

The research was a case control study. It conducted prospectively from January 2019 to December 2023 in the surgery department of Aswan university hospital. It involving patients with diabetic foot infections. The patients were divided into two groups of patients. The first group committed to not eating carbohydrates in food. The second group ate their daily routine and did not adhere to the carbohydrate's restriction. The diabetic food infection classified from mild, moderate and sever, as per the Infectious Diseases Society of America (IDSA) Infection Severity Classification.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients complained of diabetic foot infections graded 0 to 4 with absent signs of ischemia.

Exclusion criteria

Patients with foot gangrene grade 5 The presence of foot ischemia Those who refused to participate

Treatment and study plan

Carbohydrates restriction

Behavioral

Patients followed a low carbohydrate dietary approach (LCDs). It means lower than 130 grams carbohydrates per day with special restriction restrictions on:

Artificial sugars (e.g., sweets, baked goods, pasta, bread).
Also, rice, butter made from vegetable oils and all types of oils except olive oil.

They were allowed:

All types of fresh fruits and vegetable.
Boiled potatoes.

Other names: diabetic foot infection with low carbohydrates diet

Primary outcomes

Change in the wound size and healing

Time frame: 3-6 months

Wound healing rate (%) = [ (Initial wound size - Wound size after 1 week) / (Initial wound size)] × 100

Sponsors and collaborators

Lead sponsor

Sarah Magdy Abdelmohsen

Other

Registry information

Acronym: LCN

Important dates

Study start: 2019
Primary completion: 2023
Study completion: 2023
First posted: Jan 6, 2025
Registry last updated: Jan 7, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed