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OpenTrials
Completed

NCT Number: NCT00710255

Role of Leukotrienes and Adenosine in Hyperpnea-induced Bronchospasm

This research is being conducted to help us better understand what causes exercise induced asthma. The investigators hypothesize that two types of chemicals, cysteinyl leukotrienes and adenosine, play an important role. The investigators will be measuring these chemicals in the exhaled breath of volunteers with exercise induced asthma as they undergo a test to mimic exercise induced asthma. The investigators will determine how the levels of these chemicals change in association with how lung function changes before, during and after an episode of exercise induced asthma.

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Key information

Conditions

Asthma, Exercise Induced Asthma Asthma, Exercise-Induced Bronchial Diseases Exercise-Induced Allergies Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Lung Diseases Lung Diseases, Obstructive Respiratory Hypersensitivity Respiratory Tract Diseases

Age range

12 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Vermont Lung Center

Colchester, Vermont, 05446, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Physician diagnosed asthma
  • Age 12-75 yrs
  • FEV1 > 70% predicted
  • HIB response > 10 %
  • No smoking last 6 mo and < 10 pack yrs
  • No URI last 4 weeks
  • No asthma exacerbation last 4 weks
  • Able to withhold SABA > 8 hrs and LABA > 24 hrs

Exclusion criteria

  • Other lung disease
  • Cardiac disease or other condition that would preclude safe participation, on theophylline or leukotriene modifiers

Treatment and study plan

Hyperpnea challenge

Procedure

5 minutes of dry air hyperpnea to induce bronchospasm

Primary outcomes

  1. Change in level of cystLTs and adenosine

    Time frame: Before and after hyperpnea challenge

Secondary outcomes

  1. Change in pH of EBC and change in pulmonary function

    Time frame: Before and after hyperpnea challenge

Sponsors and collaborators

Lead sponsor

University of Vermont

Other

Registry information

Official study title

Role of Leukotrienes and Adenosine in Hyperpnea-induced Bronchospasm Determined by Dynamic Analysis of Exhaled Breath Condensate.

Important dates

Study start
2007
Primary completion
2009
Study completion
2009
First posted
Jul 4, 2008
Registry last updated
Oct 31, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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