Skip to main content
OpenTrials
Completed

NCT Number: NCT05672030

Role of IL-5R Signaling in Non-eosinophil Upper Airway Cells in CRSwNP

The overarching hypothesis of this proposal is that IL-5 acts on multiple sinus tissue cell types, including plasma cells and epithelial cells, to promote immune dysregulation, and that inhibition of IL-5 affects several relevant effector pathways that lead to clinical benefit.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Nasal Polyps Aspirin-exacerbated Respiratory Disease Nose Diseases Otorhinolaryngologic Diseases Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Polyps Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States

About this study

Further characterization of the role of IL-5Rα expression and function on human plasma cells will determine whether inhibiting IL-5 signaling on these cells offers therapeutic promise in other diseases related to plasma cell proliferation. Further characterization of human upper airway epithelial cell IL-5Rα expression and function will determine whether or not inhibiting IL-5 signaling on these cells offers therapeutic promise in other diseases related to epithelial dysfunction. IL-5Rα expression has been identified on several relevant sinus tissue effector cells, including on nasal polyp plasma cells and epithelial cells, and the aim of this study is to further the field by determining the consequences of IL-5 signaling on those cells.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • AERD, CRSwNP, healthy controls

Exclusion criteria

  • Not on any systemic steroids or respiratory biologics at time of surgery

Treatment and study plan

Non-Interventional

Other

No intervention.

Primary outcomes

  1. Number of Participants With Nasal Polyp Plasma Cell Transcriptome

    Time frame: At baseline

    We will determine the number of participants from whom a transcriptional profile of nasal polyp plasma cells is analyzable from bulk RNA sequencing of sorted nasal polyp plasma cells.

Secondary outcomes

  1. Number of Participants With Functional Readouts of IL-5Ra on Nasal Polyp Plasma Cells.

    Time frame: At baseline

    We will determine the number of participants from whom a readout of IL-5Ra is analyzable from the plasma cells in their nasal tissue

  2. Number of Patients for Whom IL-5Ra Signaling on Nasal Epithelial Cells Can be Analyzed

    Time frame: At baseline

    We will determine the number of participants from whom IL-5-elicited signaling on their nasal epithelial tissue can be analyzed.

Sponsors and collaborators

Lead sponsor

Brigham and Women's Hospital

Other

Registry information

Official study title

Role of Interleukin 5 (IL-5) and IL-5R Signaling in Non-eosinophil Upper Airway Cells in Chronic Rhinosinusitis With Nasal Polyps

Acronym: RECAP-5

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Jan 5, 2023
Registry last updated
Nov 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.